Form follows function: The genomic organization of cellular differentiation

Steven T. Kosak, Mark Groudine*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

174 Scopus citations

Abstract

The extent to which the nucleus is functionally organized has broad biological implications. Evidence supports the idea that basic nuclear functions, such as transcription, are structurally integrated within the nucleus. Moreover, recent studies indicate that the linear arrangement of genes within eukaryotic genomes is nonrandom. We suggest that determining the relationship between nuclear organization and the linear arrangement of genes will lead to a greater understanding of how transcriptomes, dedicated to a particular cellular function or late, are coordinately regulated. Current network theories may provide a useful framework for modeling the inherent complexity the functional organization of the nucleus.

Original languageEnglish (US)
Pages (from-to)1371-1384
Number of pages14
JournalGenes and Development
Volume18
Issue number12
DOIs
StatePublished - Jun 15 2004

Keywords

  • Expression neighborhood
  • Genetic networks
  • Genomic organization
  • Nuclear structure
  • Transcription

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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