Formation and catalytic hydrogenation of the dimer of 1,2,3,4,5,7a‐hexahydroimidazo[1,2‐a]pyrazine

Chad A. Mirkin*, Joan E. Premecz, Michael E. Ford, Thomas A. Johnson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Reaction of diethylenetriamine with glyoxal or N,N'‐dicyclohexylethylenediimine forms the novel heterocycle 1,2,3,4,5,7a‐hexahydroimidazo[1,2‐a]pyrazine 1 (R1 = R2 = H) which is isolated as its dimer. Catalytic hydrogenation converts 1 into N(2‐aminoethyl)piperazine in high yield.

Original languageEnglish (US)
Pages (from-to)839-840
Number of pages2
JournalJournal of Heterocyclic Chemistry
Issue number3
StatePublished - 1993

ASJC Scopus subject areas

  • Organic Chemistry


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