Formation and Maintenance of a Functional Glomerulus

Rizaldy P Scott*, Susan E Quaggin

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

The renal glomerulus is an elegant structure that serves as an exquisitely selective plasma filtration unit. The glomerulus has been conserved throughout evolution and has a basic cellular organization common in the primitive kidneys of fishes and amphibious vertebrates to the more advanced kidneys of birds, reptiles, and mammals. The normal development and integrity of the glomerulus are essential for the efficient removal of metabolic wastes without inadvertent loss of vital plasma components such as proteins and blood cells into urine. Intensive research over the years has uncovered the interplay between the different cells that comprise the glomerulus, and the genes that help shape and maintain glomerular integrity. We summarize here our current understanding of glomerular development and function, and recent findings providing insights into the etiology of renal disease resulting from glomerular maldevelopment and dysfunction.

Original languageEnglish (US)
Title of host publicationKidney Development, Disease, Repair and Regeneration
EditorsMH Little
Place of PublicationLondon
PublisherElsevier Science Ltd.
Pages103-119
Number of pages17
ISBN (Electronic)9780128004388
ISBN (Print)9780128001028
DOIs
StatePublished - Jan 1 2015

Keywords

  • Endothelial surface layer
  • Fenestrae
  • Glomerular basement membrane
  • Glomerular endothelial cell
  • Glomerulus
  • Mesangial cell
  • Parietal epithelial cell
  • Podocyte
  • Proteinuria
  • Slit diaphragm

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Formation and Maintenance of a Functional Glomerulus'. Together they form a unique fingerprint.

  • Cite this

    Scott, R. P., & Quaggin, S. E. (2015). Formation and Maintenance of a Functional Glomerulus. In MH. Little (Ed.), Kidney Development, Disease, Repair and Regeneration (pp. 103-119). Elsevier Science Ltd.. https://doi.org/10.1016/B978-0-12-800102-8.00010-2