Fospropofol disodium for sedation in elderly patients undergoing flexible bronchoscopy

Gerard A. Silvestri, Brad D. Vincent, Momen M. Wahidi

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background: Fospropofol disodium is a water-soluble prodrug of propofol. A subset analysis was undertaken of elderly patients (≥65 y) undergoing flexible bronchoscopy, who were part of a larger multicenter, randomized, double-blind study. Methods: Patients received fentanyl citrate (50 mcg) followed by fospropofol at initial (4.88 mg/kg) and supplemental (1.63 mg/kg) doses. The primary end point was sedation success (3 consecutive Modified Observer's Assessment of Alertness/Sedation scores of ≤4 and procedure completion without alternative sedative or assisted ventilation). Treatment success, time to fully alert, patient and physician satisfaction, and safety/tolerability were also evaluated. Results: In the elderly patients subset (n=61), sedation success was 92%, the mean time to fully alert was 8.0±10.9 min, and memory retention was 72% during recovery, and these were comparable with the younger patients subgroup (age, <65 y). Sedation-related adverse events occurred in 23% of the elderly and 18% of the younger patients (age, <65 y) group. Hypoxemia occurred in 26% of the elderly and 18% of the younger patients group, but no escalation of care was required. Conclusions: Fospropofol provided safe and effective sedation, rapid time to fully alert, and high satisfaction in this elderly subset undergoing flexible bronchoscopy, which was comparable with outcomes in younger patients.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalJournal of Bronchology and Interventional Pulmonology
Volume18
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Bronchoscopy
  • Elderly
  • Fospropofol
  • Sedation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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