Four-dimensional flow magnetic resonance imaging-based characterization of aortic morphometry and haemodynamics: Impact of age, aortic diameter, and valve morphology

Julio Garcia, Alex J. Barker, Ian Murphy, Kelly Jarvis, Susanne Schnell, Jeremy D. Collins, James C. Carr, S. Chris Malaisrie, Michael Markl*

*Corresponding author for this work

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Aims Four-dimensional (4D) flow magnetic resonance imaging (MRI) was employed for the simultaneous assessment of morphometry and flow parameters along the thoracic aorta to investigate associations between flow, age, aorta diameter, and aortic valve morphology. Methods and results One hundred and sixty-five subjects, 65 controls, 50 patients with bicuspid aortic valve (BAV), and 50 patients with a dilated aorta, and a tricuspid aortic valve (TAV) underwent 4D flow MRI. Following 3D segmentation of the aorta, a vessel centreline was calculated and used to extract aorta diameter, peak systolic velocity, and normalized systolic flow displacement. Validation of 4D flow MRI-based morphometric measurements compared with manual diameter measurements from standard contrast-enhanced MR angiography in 20 controls showed good agreement (mean difference = 0.4 mm, limits of agreement =±1.31 mm) except at the sinus of valsalva. BAV showed significant differences in average peak velocity (PV; P<0.016) compared with TAV and controls between the left ventricle outflow tract to sino-tubular junction (BAV: 1.3±0.3 m/s; TAV: 1.2±0.2 m/s; controls: 1.0±0.1 m/s) and the ascending aorta for average normalized flow displacement (BAV: 0.11±0.02; TAV: 0.09±0.02; controls: 0.06±0.01, P <0.016) despite similar average aortic dimensions for BAV (37±1 mm) and TAV (39±1 mm). Multivariate linear regression showed a significant correlation of maximal aortic diameter to age, PV, and normalized flow displacement (R2 = 0.413, P <0.001). Conclusion A single acquisition of 4D flow MRI characterized local morphological and haemodynamic differences between groups along the aorta. BAV showed altered haemodynamics when compared with TAV in spite of having similar aorta dimensions. Maximal aorta diameter was associated with age, PV, and normalized flow displacement.

Original languageEnglish (US)
Pages (from-to)877-884
Number of pages8
JournalEuropean heart journal cardiovascular Imaging
Volume17
Issue number8
DOIs
StatePublished - Jan 1 2016

Fingerprint

Aortic Valve
Tricuspid Valve
Aorta
Hemodynamics
Magnetic Resonance Imaging
Sinus of Valsalva
Thoracic Aorta
Heart Ventricles
Bicuspid Aortic Valve
Linear Models
Angiography

Keywords

  • Aortic diseases
  • Haemodynamics
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

@article{2116fbcae5de475c80f5482f52e8bfbd,
title = "Four-dimensional flow magnetic resonance imaging-based characterization of aortic morphometry and haemodynamics: Impact of age, aortic diameter, and valve morphology",
abstract = "Aims Four-dimensional (4D) flow magnetic resonance imaging (MRI) was employed for the simultaneous assessment of morphometry and flow parameters along the thoracic aorta to investigate associations between flow, age, aorta diameter, and aortic valve morphology. Methods and results One hundred and sixty-five subjects, 65 controls, 50 patients with bicuspid aortic valve (BAV), and 50 patients with a dilated aorta, and a tricuspid aortic valve (TAV) underwent 4D flow MRI. Following 3D segmentation of the aorta, a vessel centreline was calculated and used to extract aorta diameter, peak systolic velocity, and normalized systolic flow displacement. Validation of 4D flow MRI-based morphometric measurements compared with manual diameter measurements from standard contrast-enhanced MR angiography in 20 controls showed good agreement (mean difference = 0.4 mm, limits of agreement =±1.31 mm) except at the sinus of valsalva. BAV showed significant differences in average peak velocity (PV; P<0.016) compared with TAV and controls between the left ventricle outflow tract to sino-tubular junction (BAV: 1.3±0.3 m/s; TAV: 1.2±0.2 m/s; controls: 1.0±0.1 m/s) and the ascending aorta for average normalized flow displacement (BAV: 0.11±0.02; TAV: 0.09±0.02; controls: 0.06±0.01, P <0.016) despite similar average aortic dimensions for BAV (37±1 mm) and TAV (39±1 mm). Multivariate linear regression showed a significant correlation of maximal aortic diameter to age, PV, and normalized flow displacement (R2 = 0.413, P <0.001). Conclusion A single acquisition of 4D flow MRI characterized local morphological and haemodynamic differences between groups along the aorta. BAV showed altered haemodynamics when compared with TAV in spite of having similar aorta dimensions. Maximal aorta diameter was associated with age, PV, and normalized flow displacement.",
keywords = "Aortic diseases, Haemodynamics, Magnetic resonance imaging",
author = "Julio Garcia and Barker, {Alex J.} and Ian Murphy and Kelly Jarvis and Susanne Schnell and Collins, {Jeremy D.} and Carr, {James C.} and Malaisrie, {S. Chris} and Michael Markl",
year = "2016",
month = "1",
day = "1",
doi = "10.1093/ehjci/jev228",
language = "English (US)",
volume = "17",
pages = "877--884",
journal = "European Heart Journal Cardiovascular Imaging",
issn = "2047-2404",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - Four-dimensional flow magnetic resonance imaging-based characterization of aortic morphometry and haemodynamics

T2 - Impact of age, aortic diameter, and valve morphology

AU - Garcia, Julio

AU - Barker, Alex J.

AU - Murphy, Ian

AU - Jarvis, Kelly

AU - Schnell, Susanne

AU - Collins, Jeremy D.

AU - Carr, James C.

AU - Malaisrie, S. Chris

AU - Markl, Michael

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Aims Four-dimensional (4D) flow magnetic resonance imaging (MRI) was employed for the simultaneous assessment of morphometry and flow parameters along the thoracic aorta to investigate associations between flow, age, aorta diameter, and aortic valve morphology. Methods and results One hundred and sixty-five subjects, 65 controls, 50 patients with bicuspid aortic valve (BAV), and 50 patients with a dilated aorta, and a tricuspid aortic valve (TAV) underwent 4D flow MRI. Following 3D segmentation of the aorta, a vessel centreline was calculated and used to extract aorta diameter, peak systolic velocity, and normalized systolic flow displacement. Validation of 4D flow MRI-based morphometric measurements compared with manual diameter measurements from standard contrast-enhanced MR angiography in 20 controls showed good agreement (mean difference = 0.4 mm, limits of agreement =±1.31 mm) except at the sinus of valsalva. BAV showed significant differences in average peak velocity (PV; P<0.016) compared with TAV and controls between the left ventricle outflow tract to sino-tubular junction (BAV: 1.3±0.3 m/s; TAV: 1.2±0.2 m/s; controls: 1.0±0.1 m/s) and the ascending aorta for average normalized flow displacement (BAV: 0.11±0.02; TAV: 0.09±0.02; controls: 0.06±0.01, P <0.016) despite similar average aortic dimensions for BAV (37±1 mm) and TAV (39±1 mm). Multivariate linear regression showed a significant correlation of maximal aortic diameter to age, PV, and normalized flow displacement (R2 = 0.413, P <0.001). Conclusion A single acquisition of 4D flow MRI characterized local morphological and haemodynamic differences between groups along the aorta. BAV showed altered haemodynamics when compared with TAV in spite of having similar aorta dimensions. Maximal aorta diameter was associated with age, PV, and normalized flow displacement.

AB - Aims Four-dimensional (4D) flow magnetic resonance imaging (MRI) was employed for the simultaneous assessment of morphometry and flow parameters along the thoracic aorta to investigate associations between flow, age, aorta diameter, and aortic valve morphology. Methods and results One hundred and sixty-five subjects, 65 controls, 50 patients with bicuspid aortic valve (BAV), and 50 patients with a dilated aorta, and a tricuspid aortic valve (TAV) underwent 4D flow MRI. Following 3D segmentation of the aorta, a vessel centreline was calculated and used to extract aorta diameter, peak systolic velocity, and normalized systolic flow displacement. Validation of 4D flow MRI-based morphometric measurements compared with manual diameter measurements from standard contrast-enhanced MR angiography in 20 controls showed good agreement (mean difference = 0.4 mm, limits of agreement =±1.31 mm) except at the sinus of valsalva. BAV showed significant differences in average peak velocity (PV; P<0.016) compared with TAV and controls between the left ventricle outflow tract to sino-tubular junction (BAV: 1.3±0.3 m/s; TAV: 1.2±0.2 m/s; controls: 1.0±0.1 m/s) and the ascending aorta for average normalized flow displacement (BAV: 0.11±0.02; TAV: 0.09±0.02; controls: 0.06±0.01, P <0.016) despite similar average aortic dimensions for BAV (37±1 mm) and TAV (39±1 mm). Multivariate linear regression showed a significant correlation of maximal aortic diameter to age, PV, and normalized flow displacement (R2 = 0.413, P <0.001). Conclusion A single acquisition of 4D flow MRI characterized local morphological and haemodynamic differences between groups along the aorta. BAV showed altered haemodynamics when compared with TAV in spite of having similar aorta dimensions. Maximal aorta diameter was associated with age, PV, and normalized flow displacement.

KW - Aortic diseases

KW - Haemodynamics

KW - Magnetic resonance imaging

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