Fourteen nucleotides in the second complementarity-determining region of a human heavy-chain variable region gene are identical with a sequence in a human D minigene

T. T. Wu, E. A. Kabat

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

A sequence of 14 nucleotides in one human diversity (D) minigene (D2) is identical with a sequence in complementarity-determining region 2 (CDR2) of one human gene for the variable region of the heavy chain of immunoglobulin. The finding that nucleotide segments present in a D minigene can appear in CDR2 raises the possibility that other minigene segments may be involved in the generation of antibody diversity and complementarity or that nucleotide segments may move from one CDR to another by a gene conversion mechanism.

Original languageEnglish (US)
Pages (from-to)5031-5032
Number of pages2
JournalProceedings of the National Academy of Sciences of the United States of America
Volume79
Issue number16 I
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • General

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