Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation

Jes M. Sanders, Shareni Jeyamogan, James M. Mathew*, Joseph R. Leventhal*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Regulatory T cells (Tregs) are critical for tolerance in humans. The exact mechanisms by which the loss of peripheral tolerance leads to the development of autoimmunity and the specific role Tregs play in allograft tolerance are not fully understood; however, this population of T cells presents a unique opportunity in the development of targeted therapeutics. In this review, we discuss the potential roles of Foxp3+ Tregs in the development of tolerance in transplantation and autoimmunity, and the available data regarding their use as a treatment modality.

Original languageEnglish (US)
Article number1055466
JournalFrontiers in immunology
Volume13
DOIs
StatePublished - Nov 17 2022

Keywords

  • adoptive cell transfer
  • allograft tolerance
  • antigen-specific regulatory T cells
  • autoimmunity
  • regulatory T cells
  • solid organ transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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