Abstract
Regulatory T cells (Tregs) are critical for tolerance in humans. The exact mechanisms by which the loss of peripheral tolerance leads to the development of autoimmunity and the specific role Tregs play in allograft tolerance are not fully understood; however, this population of T cells presents a unique opportunity in the development of targeted therapeutics. In this review, we discuss the potential roles of Foxp3+ Tregs in the development of tolerance in transplantation and autoimmunity, and the available data regarding their use as a treatment modality.
| Original language | English (US) |
|---|---|
| Article number | 1055466 |
| Journal | Frontiers in immunology |
| Volume | 13 |
| DOIs | |
| State | Published - Nov 17 2022 |
Funding
The authors were supported by the Frankel Family Foundation. Research reported in this publication was also supported by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number T32DK077662 (Grant: T32DK077662/TR/NIAID NIH HHS/United States). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Keywords
- adoptive cell transfer
- allograft tolerance
- antigen-specific regulatory T cells
- autoimmunity
- regulatory T cells
- solid organ transplantation
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology