Fractional anisotropy in individuals with schizophrenia and their nonpsychotic siblings

Michael P. Harms*, Kazi D. Akhter, John G. Csernansky, Susumu Mori, Deanna M. Barch

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Fractional anisotropy (FA) was examined in a priori selected fiber tracts in individuals with schizophrenia (. n=25) and their non-psychotic siblings (. n=29) versus controls (. n=35). FA was reduced in a portion of the fornix in individuals with schizophrenia (although this did not survive correction for the number of tracts investigated). FA in the siblings did not differ from that in controls in any of the investigated tracts. •Fractional anisotropy (FA) was compared in individuals with schizophrenia and their siblings versus controls.•FA was reduced in a portion of the fornix in schizophrenia.•FA in siblings did not differ from that in controls.

Original languageEnglish (US)
Pages (from-to)87-91
Number of pages5
JournalPsychiatry Research - Neuroimaging
Volume231
Issue number1
DOIs
StatePublished - Jan 30 2015

Keywords

  • Diffusion tensor imaging (DTI)
  • Endophenotype
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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