Fractional moving blood volume: Estimation with power Doppler US

J. M. Rubin, R. S. Adler, J. B. Fowlkes, S. Spratt, J. E. Pallister, J. F. Chen -, P. L. Carson

Research output: Contribution to journalArticlepeer-review

273 Scopus citations


PURPOSE: To estimate the fraction of moving blood in tissue with power Doppler ultrasound (US). MATERIALS AND METHODS: Power Doppler US measurements of moving scatterers in a flow tube were made as a function of successive dilutions of the perfusate. Measurements were normalized relative to the maximum Doppler power in the center of the flow tube at the highest concentration and were used to calculate the fractional dilution of the perfusate for each run with each dilution used to represent increasing amounts of nonmoving soft tissue in the sample volume. The technique was also applied to two clinical examples. RESULTS: Successive dilutions of the perfusate in the flow experiment showed a monotonic, linear decrease in the Doppler power as a function of dilution. CONCLUSION: The power Doppler US technique has the potential to more accurately estimate alterations in blood flow and has the advantage of being a continuous parameter that can be depth normalized.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
Issue number1
StatePublished - Oct 1995


  • Blood, US
  • Blood, flow dynamics
  • Blood, volume
  • Ultrasound (US), Doppler studies
  • Ultrasound (US), technology

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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