Fractionated stereotactic radiotherapy for pediatric brain tumors: The Chicago children's experience

J. A. Kalapurakal*, A. Kepka, T. Bista, S. Goldman, T. Tomita, Maryanne Hoffman Marymont

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Thirty-three children with a total of 35 benign/malignant brain and eye neoplasms were treated with fractionated stereotactic radiotherapy. In the first 11 children immobilization for treatment was achieved with plaster of Paris casts or aquaplast masks. In the remaining 22 children the Laitinen stereoadapter was used. Radiation was delivered with noncoplanar static or rotational beams. The dose fractionation used was 50.4-60 Gy in 28-30 fractions in patients receiving treatment with curative intent, and 10-32 Gy at 2-4 Gy/fraction for reirradiation. The accuracy of daily treatment was <2 mm. After a median follow-up of 27 months, 22 of the 25 children treated with curative intent achieved local control. One child had progressive brain necrosis following 54 Gy in 30 fractions for a pontine astrocytoma. The exact etiology of this complication is unknown. This series demonstrates that in children fractionated stereotactic radiotherapy using the Laitinen stereoadapter is well tolerated and accurate and results in good local control.

Original languageEnglish (US)
Pages (from-to)296-302
Number of pages7
JournalChild's Nervous System
Issue number5
StatePublished - May 2000


  • Brain tumor
  • Children
  • Linear accelerator
  • Radiation
  • Stereotactic radiotherapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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