Free radical dna adduct 8-oh-deoxyguanosine affects activity of hp a II and msp i restriction endonucleases

Patrick W. Turk; Sigmund A. Weitzman

doi:10.3109/10715769509064038

Free radical dna adduct 8-oh-deoxyguanosine affects activity of hp a II and msp i restriction endonucleases

Patrick W. Turk^*, Sigmund A. Weitzman

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

8-OH-deoxyguanosine can diminish the ability of the restriction endonucleases Hpa II and Msp I to cleave DNA. The exact position of the adduct within the recognition site appears to determine the extent of the effect.

Original language	English (US)
Pages (from-to)	255-258
Number of pages	4
Journal	Free Radical Research
Volume	23
Issue number	3
DOIs	https://doi.org/10.3109/10715769509064038
State	Published - 1995

Keywords

8-OH-deoxyguanosine
8-hydroxyguanine
8-hydroxyl-2'deoxyguanosine
Reactive oxygen species
Restriction endonuclease

ASJC Scopus subject areas

Biochemistry

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10.3109/10715769509064038

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@article{eef58ffe993d488ba727f05849e0f1d8,

title = "Free radical dna adduct 8-oh-deoxyguanosine affects activity of hp a II and msp i restriction endonucleases",

abstract = "8-OH-deoxyguanosine can diminish the ability of the restriction endonucleases Hpa II and Msp I to cleave DNA. The exact position of the adduct within the recognition site appears to determine the extent of the effect.",

keywords = "8-OH-deoxyguanosine, 8-hydroxyguanine, 8-hydroxyl-2'deoxyguanosine, Reactive oxygen species, Restriction endonuclease",

author = "Turk, {Patrick W.} and Weitzman, {Sigmund A.}",

note = "Funding Information: Supported by a generous grant from The Buehler Center on Aging and by National Institutes of Health Grant R01 AGI 1536. We would also like to thank Steven S. Smith for his useful suggestions.",

year = "1995",

doi = "10.3109/10715769509064038",

language = "English (US)",

volume = "23",

pages = "255--258",

journal = "Free Radical Research",

issn = "1071-5762",

publisher = "Informa Healthcare",

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TY - JOUR

T1 - Free radical dna adduct 8-oh-deoxyguanosine affects activity of hp a II and msp i restriction endonucleases

AU - Turk, Patrick W.

AU - Weitzman, Sigmund A.

N1 - Funding Information: Supported by a generous grant from The Buehler Center on Aging and by National Institutes of Health Grant R01 AGI 1536. We would also like to thank Steven S. Smith for his useful suggestions.

PY - 1995

Y1 - 1995

N2 - 8-OH-deoxyguanosine can diminish the ability of the restriction endonucleases Hpa II and Msp I to cleave DNA. The exact position of the adduct within the recognition site appears to determine the extent of the effect.

AB - 8-OH-deoxyguanosine can diminish the ability of the restriction endonucleases Hpa II and Msp I to cleave DNA. The exact position of the adduct within the recognition site appears to determine the extent of the effect.

KW - 8-OH-deoxyguanosine

KW - 8-hydroxyguanine

KW - 8-hydroxyl-2'deoxyguanosine

KW - Reactive oxygen species

KW - Restriction endonuclease

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U2 - 10.3109/10715769509064038

DO - 10.3109/10715769509064038

M3 - Article

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AN - SCOPUS:0029372777

SN - 1071-5762

VL - 23

SP - 255

EP - 258

JO - Free Radical Research

JF - Free Radical Research

IS - 3

ER -

Free radical dna adduct 8-oh-deoxyguanosine affects activity of hp a II and msp i restriction endonucleases

Abstract

Keywords

ASJC Scopus subject areas

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