Free radical dna adduct 8-oh-deoxyguanosine affects activity of hp a II and msp i restriction endonucleases

Patrick W. Turk*, Sigmund A. Weitzman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

8-OH-deoxyguanosine can diminish the ability of the restriction endonucleases Hpa II and Msp I to cleave DNA. The exact position of the adduct within the recognition site appears to determine the extent of the effect.

Original languageEnglish (US)
Pages (from-to)255-258
Number of pages4
JournalFree Radical Research
Volume23
Issue number3
DOIs
StatePublished - 1995

Keywords

  • 8-OH-deoxyguanosine
  • 8-hydroxyguanine
  • 8-hydroxyl-2'deoxyguanosine
  • Reactive oxygen species
  • Restriction endonuclease

ASJC Scopus subject areas

  • Biochemistry

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