Frequency and Detection of Insulin Infusion Site Failure in the Type 1 Diabetes Exchange Online Community

Michael S. Hughes; Julia L. Douvas; Madison Layfield-Bryan; Luis E. Blanco; John Clark Gray; Grzegorz Zapotoczny; Juan Espinoza; John H. Wilcox; Rayhan A. Lal

doi:10.1089/dia.2023.0005

Frequency and Detection of Insulin Infusion Site Failure in the Type 1 Diabetes Exchange Online Community

Michael S. Hughes, Julia L. Douvas, Madison Layfield-Bryan, Luis E. Blanco, John Clark Gray, Grzegorz Zapotoczny, Juan Espinoza, John H. Wilcox, Rayhan A. Lal^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Insulin infusion site (IIS) failures are a weakness in insulin pump therapy. We examined experience with IIS failures among U.S. individuals with diabetes on insulin pump through survey distributed to the T1D Exchange Online Community. Demographic factors, IIS characteristics, and diabetes-related perceptions were assessed by logistic regression to determine odds of higher (≥1 per month) or lower (<1 per month) reported IIS failure frequency. IIS failures were common; 41.4% reported ≥1 per month. IIS failure is usually detected through development of hyperglycemia rather than pump alarm. No assessed demographic factor or IIS characteristic was predictive; however, higher odds of ≥1 failure per month were associated with feelings of burnout (odds ratios [OR] 1.489 [1.024, 2.165]) and considering pump discontinuation (OR 2.233 [1.455, 3.427]). IIS failures are frequent and unpredictable, typically require hyperglycemia for detection, and are associated with negative perceptions. More should be done toward preventing IIS failures and/or detecting them sooner.

Original language	English (US)
Pages (from-to)	426-430
Number of pages	5
Journal	Diabetes Technology and Therapeutics
Volume	25
Issue number	6
DOIs	https://doi.org/10.1089/dia.2023.0005
State	Published - Jun 1 2023

Funding

Creation and distribution of the survey were funded by Diatech Diabetes, Inc. The T1D Exchange is supported through the Leona M. and Harry B. Helmsley Charitable Trust. M.S.H. is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) under Award Number 5K12 DK122550. R.A.L. is supported by a Diabetes, Endocrinology and Metabolism Career Development Grant (1K23 DK122017, P30 DK116074) from NIDDK and has additional research support from JDRF. Creation and distribution of the survey were funded by Diatech Diabetes, Inc. The T1D Exchange is supported through the Leona M. and Harry B. Helmsley Charitable Trust. M.S.H. is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) under Award Number 5K12 DK122550. R.A.L. is supported by a Diabetes, Endocrinology and Metabolism Career Development Grant (1K23 DK122017, P30 DK116074) from NIDDK and has additional research support from JDRF.

Keywords

Failure
Insulin infusion set
Insulin infusion site
Insulin pump
Pump malfunction

ASJC Scopus subject areas

Medical Laboratory Technology
Endocrinology
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1089/dia.2023.0005

Cite this

@article{87c6197ccfc542c5bb74672192b14763,

title = "Frequency and Detection of Insulin Infusion Site Failure in the Type 1 Diabetes Exchange Online Community",

abstract = "Insulin infusion site (IIS) failures are a weakness in insulin pump therapy. We examined experience with IIS failures among U.S. individuals with diabetes on insulin pump through survey distributed to the T1D Exchange Online Community. Demographic factors, IIS characteristics, and diabetes-related perceptions were assessed by logistic regression to determine odds of higher (≥1 per month) or lower (<1 per month) reported IIS failure frequency. IIS failures were common; 41.4% reported ≥1 per month. IIS failure is usually detected through development of hyperglycemia rather than pump alarm. No assessed demographic factor or IIS characteristic was predictive; however, higher odds of ≥1 failure per month were associated with feelings of burnout (odds ratios [OR] 1.489 [1.024, 2.165]) and considering pump discontinuation (OR 2.233 [1.455, 3.427]). IIS failures are frequent and unpredictable, typically require hyperglycemia for detection, and are associated with negative perceptions. More should be done toward preventing IIS failures and/or detecting them sooner.",

keywords = "Failure, Insulin infusion set, Insulin infusion site, Insulin pump, Pump malfunction",

author = "Hughes, {Michael S.} and Douvas, {Julia L.} and Madison Layfield-Bryan and Blanco, {Luis E.} and Gray, {John Clark} and Grzegorz Zapotoczny and Juan Espinoza and Wilcox, {John H.} and Lal, {Rayhan A.}",

year = "2023",

month = jun,

day = "1",

doi = "10.1089/dia.2023.0005",

language = "English (US)",

volume = "25",

pages = "426--430",

journal = "Diabetes Technology and Therapeutics",

issn = "1520-9156",

publisher = "Mary Ann Liebert Inc.",

number = "6",

}

TY - JOUR

T1 - Frequency and Detection of Insulin Infusion Site Failure in the Type 1 Diabetes Exchange Online Community

AU - Hughes, Michael S.

AU - Douvas, Julia L.

AU - Layfield-Bryan, Madison

AU - Blanco, Luis E.

AU - Gray, John Clark

AU - Zapotoczny, Grzegorz

AU - Espinoza, Juan

AU - Wilcox, John H.

AU - Lal, Rayhan A.

PY - 2023/6/1

Y1 - 2023/6/1

N2 - Insulin infusion site (IIS) failures are a weakness in insulin pump therapy. We examined experience with IIS failures among U.S. individuals with diabetes on insulin pump through survey distributed to the T1D Exchange Online Community. Demographic factors, IIS characteristics, and diabetes-related perceptions were assessed by logistic regression to determine odds of higher (≥1 per month) or lower (<1 per month) reported IIS failure frequency. IIS failures were common; 41.4% reported ≥1 per month. IIS failure is usually detected through development of hyperglycemia rather than pump alarm. No assessed demographic factor or IIS characteristic was predictive; however, higher odds of ≥1 failure per month were associated with feelings of burnout (odds ratios [OR] 1.489 [1.024, 2.165]) and considering pump discontinuation (OR 2.233 [1.455, 3.427]). IIS failures are frequent and unpredictable, typically require hyperglycemia for detection, and are associated with negative perceptions. More should be done toward preventing IIS failures and/or detecting them sooner.

AB - Insulin infusion site (IIS) failures are a weakness in insulin pump therapy. We examined experience with IIS failures among U.S. individuals with diabetes on insulin pump through survey distributed to the T1D Exchange Online Community. Demographic factors, IIS characteristics, and diabetes-related perceptions were assessed by logistic regression to determine odds of higher (≥1 per month) or lower (<1 per month) reported IIS failure frequency. IIS failures were common; 41.4% reported ≥1 per month. IIS failure is usually detected through development of hyperglycemia rather than pump alarm. No assessed demographic factor or IIS characteristic was predictive; however, higher odds of ≥1 failure per month were associated with feelings of burnout (odds ratios [OR] 1.489 [1.024, 2.165]) and considering pump discontinuation (OR 2.233 [1.455, 3.427]). IIS failures are frequent and unpredictable, typically require hyperglycemia for detection, and are associated with negative perceptions. More should be done toward preventing IIS failures and/or detecting them sooner.

KW - Failure

KW - Insulin infusion set

KW - Insulin infusion site

KW - Insulin pump

KW - Pump malfunction

UR - http://www.scopus.com/inward/record.url?scp=85160967839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85160967839&partnerID=8YFLogxK

U2 - 10.1089/dia.2023.0005

DO - 10.1089/dia.2023.0005

M3 - Article

C2 - 36856574

AN - SCOPUS:85160967839

SN - 1520-9156

VL - 25

SP - 426

EP - 430

JO - Diabetes Technology and Therapeutics

JF - Diabetes Technology and Therapeutics

IS - 6

ER -

Frequency and Detection of Insulin Infusion Site Failure in the Type 1 Diabetes Exchange Online Community

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this