Frequency of hypercholesterolemia after cardiac transplantation

Jonathan S. Stamler, Douglas E. Vaughan, M. Audrey Rudd, Gilbert H. Mudge, James Kirshenbaum, Pia Young, R. Wayne Alexander, Joseph Loscalzo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

Cardiac transplant patients are prone to accelerated coronary atherosclerosis. The mechanism by which this process occurs is not yet known, although immunologically mediated arterial injury is thought to play a primary role in its pathogenesis. Despite immunosuppressive potency, patients treated with cyclosporin A remain at significant risk for the development of accelerated atherosclerosis. It is hypothesized that cyclosporin A's hepatotoxic effects might contribute to the atherosclerotic process by impairing low density lipoprotein hepatic clearance in transplant patients, which would be reflected in a more atherogenic lipoprotein profile. To test this hypothesis, serum cholesterol levels were analyzed after transplantation. Significant and progressive increases in total cholesterol and in the total-to-high density lipoprotein cholesterol ratio were found. This atherogenic lipoprotein profile may contribute to accelerated atherosclerosis in cardiac transplant patients treated with cyclosporin A.

Original languageEnglish (US)
Pages (from-to)1268-1272
Number of pages5
JournalThe American journal of cardiology
Volume62
Issue number17
DOIs
StatePublished - Dec 1 1988

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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