Frequency of pilin antigenic variation in Neisseria gonorrhoeae

C. D. Serkin, H. S. Seifert*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Variation of the pilus of Neisseria gonorrhoeae occurs by the recombination of silent pilin DNA sequences into the pilin expression locus. We have developed a quantitative, competitive reverse transcription-PCR assay which measures the frequency of pilin antigenic variation independently of changes in gonococcal colony morphology and have determined this frequency within a gonococcal population. We have also studied the frequency of antigenic variation during growth and have concluded that growth does not dramatically influence the frequency of pilin antigenic variation, although a reproducible, twofold increase is observed upon the transition into late log/stationary phase.

Original languageEnglish (US)
Pages (from-to)1955-1958
Number of pages4
JournalJournal of bacteriology
Issue number7
StatePublished - 1998

ASJC Scopus subject areas

  • Molecular Biology
  • Microbiology


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