Frequent truncating mutations of STAG2 in bladder cancer

David A. Solomon, Jung Sik Kim, Jolanta Bondaruk, Shahrokh F. Shariat, Zeng Feng Wang, Abdel G. Elkahloun, Tomoko Ozawa, Julia Gerard, Dazhong Zhuang, Shizhen Zhang, Neema Navai, Arlene Siefker-Radtke, Joanna J. Phillips, Brian D. Robinson, Mark A. Rubin, Björn Volkmer, Richard Hautmann, Rainer Küfer, Pancras C W Hogendoorn, George NettoDan Theodorescu, C. David James, Bogdan Czerniak, Markku Miettinen, Todd Waldman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

123 Scopus citations

Abstract

Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.

Original languageEnglish (US)
Pages (from-to)1428-1430
Number of pages3
JournalNature Genetics
Volume45
Issue number12
DOIs
StatePublished - Dec 2013

ASJC Scopus subject areas

  • Genetics

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