From fly wings to targeted cancer therapies: A centennial for notch signaling

Panagiotis Ntziachristos, Jing Shan Lim, Julien Sage*, Iannis Aifantis

*Corresponding author for this work

Research output: Contribution to journalReview article

202 Scopus citations

Abstract

Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago, Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a variety of organisms and tissues. However, in the past 20 years, accumulating evidence has linked alterations in the Notch pathway to tumorigenesis. In this review, we discuss the protumorigenic and tumor-suppressive functions of Notch signaling, and dissect the molecular mechanisms that underlie these functions in hematopoietic cancers and solid tumors. Finally, we link these mechanisms and observations to possible therapeutic strategies targeting the Notch pathway in human cancers.

Original languageEnglish (US)
Pages (from-to)318-334
Number of pages17
JournalCancer Cell
Volume25
Issue number3
DOIs
StatePublished - Mar 17 2014

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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