Abstract
As increasing information is available from genomic databases, mass spectrometry has begun to be used to identify and/or assess regions of predicted DNA or protein sequence. Mass spectrometry performance limits, together with experiments designed for genomic interplay, are being extended to allow accurate genotyping and protein profiling of cells at rates commensurate with the data-intensive future of biology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | R37-R45 |
| Journal | Chemistry and Biology |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2000 |
Funding
The author thanks the National Institute of Allergy and Infectious Diseases for postdoctoral (F32 AI10087) and likely transitional career support (K22 AI01748). Figures 1, 3 and 4 were adapted from those provided by Daniel Little (Sequenom), Dave Horn (McLafferty research group), and Steven Gygi (Aebersold research group), respectively; the author thanks these researchers and Peter Belshaw, Chris Hendrickson, Jim Vath and Christopher Walsh for helpful comments and discussions.
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Drug Discovery
- Clinical Biochemistry