From unicuspid to quadricuspid: Influence of aortic valve morphology on aortic three-dimensional hemodynamics

Pegah Entezari, Susanne Schnell, Riti Mahadevia, Chris Malaisrie, Patrick McCarthy, Marla Mendelson, Jeremy Collins, James C. Carr, Michael Markl*, Alex J. Barker

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Materials and Methods: Aortic three-dimensional (3D) blood flow was evaluated by 4D flow MRI in 14 healthy volunteers with normal trileaflet valves and 14 patients with unicuspid (n = 3), bicuspid (n = 9, 3 "true" bicuspid, 3 right-left (RL), 3 right-noncoronary (RN) leaflet fusion, and quadricuspid aortic valves (n = 2). Data analysis included the co-registered visualization of aortic valve morphology with systolic 3D blood flow. The influence of valve morphology on aortic hemodynamics was quantified by valve flow angle.

Results: All RL-bicuspid aortic valve (BAV) were associated with flow jets directed toward the right anterior aortic wall while RN-fusion and unicuspid valves resulted in flow jet patterns toward the right-posterior or posterior wall. Flow angles were clearly influenced by valve morphology (47° ±10, 28° ±2, 29° ±18, 18° ±12, 15° ±2 for unicuspid, true BAV, RN-BAV, RL-BAV, quadricuspid valves) and increased compared with controls (7.2° ± 1.1, P=0.001).

Conclusion: Altered 3D aortic hemodynamics are impacted by the morphology of congenitally malformed aortic valves.

Purpose: To assess the impact of aortic valve morphology on aortic hemodynamics between normal tricuspid and congenitally anomalous aortic valves ranging from unicuspid to quadricuspid morphology.

Original languageEnglish (US)
Pages (from-to)1342-1346
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume40
Issue number6
DOIs
StatePublished - Dec 1 2014

Keywords

  • 4D flow MRI
  • Aortic valve
  • Bicuspid valve
  • Hemodynamics
  • Quadricuspid valve
  • Unicuspid valve

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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