Frontal lobe dysfunction following infarction of the left-sided medial thalamus

Thomas A. Sandson*, Kirk R. Daffner, Marsel Mesulam, Paulo A. Carvalho

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


We treated a 62-year-old woman who developed a dramatic change in personality and behavior following a discrete left-sided medial thalamic infarction involving the dorsomedial nucleus. Neuropsychological testing demonstrated severe impairment of complex executive behaviors that are usually associated with frontal lobe function. Electroencephalography and single-photon emission computed tomography strongly implicated dysfunction of the ipsilateral frontal lobe. This case further supports a functional and physiologic thalamofrontal linkage as part of a broader cerebral network modulating complex human behavior.

Original languageEnglish (US)
Pages (from-to)1300-1303
Number of pages4
JournalArchives of Neurology
Issue number12
StatePublished - Dec 1991

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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