Frontiers in cancer immunotherapy—a symposium report

Jennifer Cable*, Benjamin Greenbaum, Dana Pe'er, Catherine M. Bollard, Sofia Bruni, Matthew E. Griffin, James P. Allison, Catherine J. Wu, Sumit K. Subudhi, Elaine R. Mardis, Renier Brentjens, Jeffry A. Sosman, Saso Cemerski, Anastasia Maria Zavitsanou, Theresa Proia, Mikala Egeblad, Garry Nolan, Sangeeta Goswami, Stefani Spranger, Crystal L. Mackall

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Cancer immunotherapy has dramatically changed the approach to cancer treatment. The aim of targeting the immune system to recognize and destroy cancer cells has afforded many patients the prospect of achieving deep, long-term remission and potential cures. However, many challenges remain for achieving the goal of effective immunotherapy for all cancer patients. Checkpoint inhibitors have been able to achieve long-term responses in a minority of patients, yet improving response rates with combination therapies increases the possibility of toxicity. Chimeric antigen receptor T cells have demonstrated high response rates in hematological cancers, although most patients experience relapse. In addition, some cancers are notoriously immunologically “cold” and typically are not effective targets for immunotherapy. Overcoming these obstacles will require new strategies to improve upon the efficacy of current agents, identify biomarkers to select appropriate therapies, and discover new modalities to expand the accessibility of immunotherapy to additional tumor types and patient populations.

Original languageEnglish (US)
Pages (from-to)30-47
Number of pages18
JournalAnnals of the New York Academy of Sciences
Volume1489
Issue number1
DOIs
StatePublished - Apr 16 2021

Keywords

  • CAR T
  • T cell therapy
  • cancer vaccine
  • checkpoint inhibitors
  • immune evasion
  • immuno-oncology
  • immunogenomics
  • immunotherapy
  • neoantigen
  • tumor microenvironment

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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