Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8 + T cells

Debra K. Newman*, Guoping Fu, Laura McOlash, David Schauder, Peter J. Newman, Weiguo Cui, Sridhar Rao, Bryon D. Johnson, Jill A. Gershan, Matthew J. Riese

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Inhibitory cell surface proteins on T cells are often dynamically regulated, which contributes to their physiologic function. PECAM-1 (CD31) is an inhibitory receptor that facilitates TGF-β-mediated suppression of T cell activity. It is well established in CD4 + T cells that PECAM-1 is expressed in naïve recent thymic emigrants, but is down-regulated after acute T cell activation and absent from memory cells. The extent to which PECAM-1 expression is similarly regulated in CD8 + T cells is much less well characterized. We evaluated T cells recovered from mice after infection with a model intracellular pathogen and determined that, in CD8 + T cells, PECAM-1 expression was strongly down-regulated during acute infection but re-expressed to intermediate levels in memory cells. Down-regulation of PECAM-1 expression in CD8 + T cells was transcriptionally regulated and affected by the strength and nature of TCR signaling. PECAM-1 was also detected on the surface of human activated/memory CD8 + , but not CD4 + T cells. These data demonstrate that PECAM-1 expression is dynamically regulated, albeit differently, in both CD4 + and CD8 + T cells. Furthermore, unlike memory CD4 + T cells, memory CD8 + T cells retain PECAM-1 expression and have the potential to be modulated by this inhibitory receptor.

Original languageEnglish (US)
Pages (from-to)883-893
Number of pages11
JournalJournal of Leukocyte Biology
Issue number5
StatePublished - Nov 2018


  • CD8 T cell
  • Listeria monocytogenes
  • PECAM-1
  • diacylglycerol kinase zeta

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology


Dive into the research topics of 'Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8 + T cells'. Together they form a unique fingerprint.

Cite this