Frontostriatal pathways gate processing of behaviorally relevant reward dimensions

Susanna C. Weber, Thorsten Kahnt, Boris B. Quednow, Philippe N. Tobler

Research output: Contribution to journalArticle

Abstract

The value of rewards arises from multiple hedonic and motivational dimensions. Reward-encoding brain regions such as the ventral striatum (VS) are known to process these dimensions. However, the mechanism whereby distinct reward dimensions are selected for neural processing and guiding behavior remains unclear. Here, we used functional imaging to investigate how human individuals make either hedonic (liking) or motivational (wanting) evaluations of everyday items. We found that the two types of evaluations were differently modulated depending on whether participants won or lost these items. Neural activity in the VS encoded both hedonic and motivational dimensions of reward, whereas ventromedial prefrontal activity encoded primarily motivational evaluations and central orbitofrontal activity encoded predominantly hedonic evaluations. These distinct prefrontal representations arose regardless of which judgment was currently relevant for behavior. Critically, the VS preferentially processed the reward dimension currently being evaluated and showed judgment-specific functional connectivity with the dimension-specific prefrontal areas. Thus, our data are in line with a gating mechanism by which prefrontal cortex (PFC)-VS pathways flexibly encode reward dimensions depending on their behavioral relevance. These findings provide a prototype for a generalized information selection mechanism through content-tailored frontostriatal communication.

Original languageEnglish (US)
Pages (from-to)e2005722
JournalPLoS biology
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2018

Fingerprint

Reward
Brain
Pleasure
Imaging techniques
Communication
Processing
Prefrontal Cortex
prototypes
animal communication
image analysis
Ventral Striatum
brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Weber, Susanna C. ; Kahnt, Thorsten ; Quednow, Boris B. ; Tobler, Philippe N. / Frontostriatal pathways gate processing of behaviorally relevant reward dimensions. In: PLoS biology. 2018 ; Vol. 16, No. 10. pp. e2005722.
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Frontostriatal pathways gate processing of behaviorally relevant reward dimensions. / Weber, Susanna C.; Kahnt, Thorsten; Quednow, Boris B.; Tobler, Philippe N.

In: PLoS biology, Vol. 16, No. 10, 01.10.2018, p. e2005722.

Research output: Contribution to journalArticle

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