Fully automated fiber-based optical spectroscopy system for use in a clinical setting

Adam Eshein, Andrew J. Radosevich, Bradley Gould, Wenli Wu, Vani Konda, Leslie W. Yang, Ann Koons, Seth Feder, Vesta Valuckaite, Hemant K. Roy, Vadim Backman, The Quyen Nguyen*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

While there are a plethora of in vivo fiber-optic spectroscopic techniques that have demonstrated the ability to detect a number of diseases in research trials with highly trained personnel familiar with the operation of experimental optical technologies, very few techniques show the same level of success in large multicenter trials. To meet the stringent requirements for a viable optical spectroscopy system to be used in a clinical setting, we developed components including an automated calibration tool, optical contact sensor for signal acquisition, and a methodology for real-time in vivo probe calibration correction. The end result is a state-of-the-art medical device that can be realistically used by a physician with spectroscopic fiber-optic probes. We show how the features of this system allow it to have excellent stability measuring two scattering phantoms in a clinical setting by clinical staff with ∼0.5 % standard deviation over 25 unique measurements on different days. In addition, we show the systems' ability to overcome many technical obstacles that spectroscopy applications often face such as speckle noise and user variability. While this system has been designed and optimized for our specific application, the system and design concepts are applicable to most in vivo fiber-optic-based spectroscopic techniques.

Original languageEnglish (US)
Article number075003
JournalJournal of Biomedical Optics
Volume23
Issue number7
DOIs
StatePublished - Jul 1 2018

Keywords

  • automated systems
  • fiber-optics
  • medical optics
  • spectroscopy
  • tissue optics

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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    Eshein, A., Radosevich, A. J., Gould, B., Wu, W., Konda, V., Yang, L. W., Koons, A., Feder, S., Valuckaite, V., Roy, H. K., Backman, V., & Nguyen, T. Q. (2018). Fully automated fiber-based optical spectroscopy system for use in a clinical setting. Journal of Biomedical Optics, 23(7), [075003]. https://doi.org/10.1117/1.JBO.23.7.075003