@article{9859a955ce0c4bcd9e5459b16703cc74,
title = "Fully implantable and bioresorbable cardiac pacemakers without leads or batteries",
abstract = "Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology.",
author = "Choi, {Yeon Sik} and Yin, {Rose T.} and Anna Pfenniger and Jahyun Koo and Raudel Avila and {Benjamin Lee}, K. and Chen, {Sheena W.} and Geumbee Lee and Gang Li and Yun Qiao and Alejandro Murillo-Berlioz and Alexi Kiss and Shuling Han and Lee, {Seung Min} and Chenhang Li and Zhaoqian Xie and Chen, {Yu Yu} and Amy Burrell and Beth Geist and Hyoyoung Jeong and Joohee Kim and Yoon, {Hong Joon} and Anthony Banks and Kang, {Seung Kyun} and Zhang, {Zheng Jenny} and Haney, {Chad R.} and Sahakian, {Alan Varteres} and David Johnson and Tatiana Efimova and Yonggang Huang and Trachiotis, {Gregory D.} and Knight, {Bradley P.} and Arora, {Rishi K.} and Efimov, {Igor R.} and Rogers, {John A.}",
note = "Funding Information: This work made use of the NUFAB facility of Northwestern University{\textquoteright}s NUANCE Center, which has received support from the Soft and Hybrid Nanotechnology Experimental Resource (NSF no. ECCS-1542205); the MRSEC program (NSF no. DMR-1720139) at the Materials Research Center; the International Institute for Nanotechnology (IIN); the Keck Foundation; and the State of Illinois, through the IIN. This work was also performed in part at The George Washington University Nanofabrication and Imaging Center. We acknowledge support from the Leducq Foundation projects RHYTHM and R01-HL141470 (to I.R.E. and J.A.R.). R.T.Y. acknowledges support from the American Heart Association Predoctoral Fellowship (no. 19PRE34380781). R.A. acknowledges support from the National Science Foundation Graduate Research Fellowship (NSF no. 1842165) and the Ford Foundation Predoctoral Fellowship. Z.X. acknowledges the support from the National Natural Science Foundation of China (grant no. 12072057) and Fundamental Research Funds for the Central Universities (grant no. DUT20RC(3)032). B.P.K. and D.J. acknowledge support from a research donation by Mr and Mrs Ronald and JoAnne Willens. We thank NU Comprehensive Transplant Center Microsurgery Core for help with cardiac implantation surgical procedures. We also thank the Washington Regional Transplant Community, heart organ donors and families of the donors; our research would not have been possible without their generous donations and support. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2021",
month = oct,
doi = "10.1038/s41587-021-00948-x",
language = "English (US)",
volume = "39",
pages = "1228--1238",
journal = "Nature Biotechnology",
issn = "1087-0156",
publisher = "Nature Publishing Group",
number = "10",
}