Fulminant Demyelinating Diseases of the Central Nervous System

Carolyn J. Bevan, Bruce A. Cree*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Fulminant demyelinating diseases of the central nervous system include acute disseminated encephalomyelitis, the related acute hemorrhagic leukoencephalitis, multiple sclerosis variants, neuromyelitis optica spectrum disorders, and idiopathic transverse myelitis. These syndromes are often managed with similar acute treatments including high-dose corticosteroids and plasmapheresis; however, long-term management varies. Although the prognosis of fulminant demyelinating disease was historically poor, outcomes today may be improved due to earlier diagnosis, rapid implementation of anti-inflammatory therapies such as high-dose corticosteroids and plasmapheresis, and improved supportive care.

Original languageEnglish (US)
Pages (from-to)656-666
Number of pages11
JournalSeminars in Neurology
Issue number6
StatePublished - Dec 1 2015


  • Balo's concentric sclerosis
  • Marburg variant of multiple sclerosis
  • acute disseminated encephalomyelitis
  • multiple sclerosis
  • neuromyelitis optica
  • transverse myelitis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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