Function and cell distribution of KC-1, a novel natural killer cell associated antigen

C. Clayberger, B. Dyer, B. McIntyre, T. D. Koller, B. Hardy, P. Parham, L. L. Lanier, A. M. Krensky

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Natural killer (NK) cells have been implicated in immune responses to tumor and viral antigens. We describe here a monoclonal antibody, anti-KC-1, that blocks lysis of NK targets by fresh but not activated NK cells. Anti-KC-1 has no effect on cytotoxic T lymphocyte activity or on antibody-dependent cellular cytotoxicity. This antibody may be useful in the analysis of NK cell activation and the mechanism of lysis.

Original languageEnglish (US)
Pages (from-to)1537-1541
Number of pages5
JournalJournal of Immunology
Volume136
Issue number5
StatePublished - Aug 6 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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