Function and cell distribution of KC-1, a novel natural killer cell associated antigen

C. Clayberger; B. Dyer; B. McIntyre; T. D. Koller; B. Hardy; P. Parham; L. L. Lanier; A. M. Krensky

Function and cell distribution of KC-1, a novel natural killer cell associated antigen

C. Clayberger, B. Dyer, B. McIntyre, T. D. Koller, B. Hardy, P. Parham, L. L. Lanier, A. M. Krensky

Research output: Contribution to journal › Article › peer-review

Abstract

Natural killer (NK) cells have been implicated in immune responses to tumor and viral antigens. We describe here a monoclonal antibody, anti-KC-1, that blocks lysis of NK targets by fresh but not activated NK cells. Anti-KC-1 has no effect on cytotoxic T lymphocyte activity or on antibody-dependent cellular cytotoxicity. This antibody may be useful in the analysis of NK cell activation and the mechanism of lysis.

Original language	English (US)
Pages (from-to)	1537-1541
Number of pages	5
Journal	Journal of Immunology
Volume	136
Issue number	5
State	Published - 1986

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Function and cell distribution of KC-1, a novel natural killer cell associated antigen",

abstract = "Natural killer (NK) cells have been implicated in immune responses to tumor and viral antigens. We describe here a monoclonal antibody, anti-KC-1, that blocks lysis of NK targets by fresh but not activated NK cells. Anti-KC-1 has no effect on cytotoxic T lymphocyte activity or on antibody-dependent cellular cytotoxicity. This antibody may be useful in the analysis of NK cell activation and the mechanism of lysis.",

author = "C. Clayberger and B. Dyer and B. McIntyre and Koller, \{T. D.\} and B. Hardy and P. Parham and Lanier, \{L. L.\} and Krensky, \{A. M.\}",

year = "1986",

language = "English (US)",

volume = "136",

pages = "1537--1541",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "American Association of Immunologists",

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TY - JOUR

T1 - Function and cell distribution of KC-1, a novel natural killer cell associated antigen

AU - Clayberger, C.

AU - Dyer, B.

AU - McIntyre, B.

AU - Koller, T. D.

AU - Hardy, B.

AU - Parham, P.

AU - Lanier, L. L.

AU - Krensky, A. M.

PY - 1986

Y1 - 1986

N2 - Natural killer (NK) cells have been implicated in immune responses to tumor and viral antigens. We describe here a monoclonal antibody, anti-KC-1, that blocks lysis of NK targets by fresh but not activated NK cells. Anti-KC-1 has no effect on cytotoxic T lymphocyte activity or on antibody-dependent cellular cytotoxicity. This antibody may be useful in the analysis of NK cell activation and the mechanism of lysis.

AB - Natural killer (NK) cells have been implicated in immune responses to tumor and viral antigens. We describe here a monoclonal antibody, anti-KC-1, that blocks lysis of NK targets by fresh but not activated NK cells. Anti-KC-1 has no effect on cytotoxic T lymphocyte activity or on antibody-dependent cellular cytotoxicity. This antibody may be useful in the analysis of NK cell activation and the mechanism of lysis.

UR - https://www.scopus.com/pages/publications/0022589986

UR - https://www.scopus.com/inward/citedby.url?scp=0022589986&partnerID=8YFLogxK

M3 - Article

C2 - 3081628

AN - SCOPUS:0022589986

SN - 0022-1767

VL - 136

SP - 1537

EP - 1541

JO - Journal of Immunology

JF - Journal of Immunology

IS - 5

ER -

Function and cell distribution of KC-1, a novel natural killer cell associated antigen

Abstract

ASJC Scopus subject areas

UN SDGs

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