Functional antibody arrays through metal ion-affinity templates

Rafael A. Vega, Daniel Maspoch, Clifton K.F. Shen, Joseph J. Kakkassery, Benjamin J. Chen, Robert A. Lamb, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

(Figure Presented) Immobile but active. Unmodified antibodies can be immobilized in an active state on arrays of patterned features coupled with metal-ions by using dippen nanolithography and microcontact printing. Their immunoreactivity was determined by atomic force and fluorescence microscopy after the arrays had been exposed to their corresponding protein or virus antigens. An example of a functional antibody array used to capture the influenza virus is shown in the AFM image.

Original languageEnglish (US)
Pages (from-to)1653-1657
Number of pages5
JournalChemBioChem
Volume7
Issue number11
DOIs
StatePublished - Nov 2006

Keywords

  • Biorecognition
  • Metal ions
  • Scanning probe microscopy
  • Surface chemistry
  • Viruses

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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