Functional decline in the aphasic variant of Alzheimer's disease

Stacey Moeller*, Jaiashre Sridhar, Adam Martersteck, Christina Coventry, Alan Kuang, Hui Zhang, Sandra Weintraub, M. Marsel Mesulam, Emily Rogalski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Introduction: Primary progressive aphasia (PPA) is a clinical dementia syndrome associated with frontotemporal lobar degeneration (FTLD) or Alzheimer's disease (AD). Impairment in activities of daily living is essential for dementia diagnosis, yet less is known about the neuropathologic impact on functional decline in PPA, especially over time. Methods: Activities of Daily Living Questionnaire (ADLQ) ratings were compared by suspected underlying pathology between 17 PPAAβ+ and 11 PPAAβ– participants at 6-month intervals for 2 years using a linear mixed-effects model. A general linear model examined associations between functional decline and cortical thickness at baseline. Results: Groups did not differ in demographics or aphasia severity at baseline, yet overall and subdomain scores of the ADLQ were significantly worse for PPAAβ+ compared to PPAAβ- (P =.015) at each interval across 18 months. Discussion: Functional decline appears more pronounced and disrupts more aspects of life activities for individuals with non-semantic PPA with suspected AD versus non-AD neuropathology.

Original languageEnglish (US)
Pages (from-to)1641-1648
Number of pages8
JournalAlzheimer's and Dementia
Issue number10
StatePublished - Oct 2021


  • activities of daily living
  • dementia
  • frontotemporal dementia
  • primary progressive aphasia

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Health Policy
  • Developmental Neuroscience
  • Epidemiology


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