Functional Disorders: Slow-Transit Constipation

John Tillou, Vitaliy Poylin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Constipation is a very common complaint, with slow-transit constipation (STC) accounting for a significant proportion of cases. Old age, female gender, psychiatric illness, and history of sexual abuse are all associated with STC. The exact cause of STC remains elusive; however, multiple immune and cellular changes have been demonstrated. Diagnosis requires evidence of slowed colonic transit which may be achieved via numerous modalities. While a variety of medical therapies exist, these are often met with limited success and a minority of patients ultimately require operative intervention. When evaluating a patient with STC, it is important to determine the presence of concomitant obstructed defecation or other forms of enteric dysmotility, as this may affect treatment decisions. Although a variety of surgical procedures have been reported, subtotal colectomy with ileorectal anastomosis is the most commonly performed and well-studied procedure, with the best track record of success.

Original languageEnglish (US)
Article number00770
Pages (from-to)76-86
Number of pages11
JournalClinics in Colon and Rectal Surgery
Issue number1
StatePublished - Feb 1 2017


  • colonic inertia
  • slow-transit constipation
  • surgical management of constipation

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology


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