Functional mapping of human learning: A positron emission tomography activation study of eyeblink conditioning

Teresa A. Blaxton*, Thomas A. Zeffiro, John D.E. Gabriell, Susan Y. Bookheimer, Maria C. Carrillo, William H. Theodore, John F Disterhoft

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

148 Scopus citations

Abstract

Regional cerebral blood flow (rCBF) was measured using positron emission tomography during eyeblink conditioning in young adults. Subjects were scanned in three experimental conditions: delay conditioning, in which binaural tones preceded air puffs to the right eye by 400 reset; pseudoconditioning in which presentations of tone and air puff stimuli were not correlated in time; and fixation rest, which served as a baseline control. Compared with fixation, pseudoconditioning produced rCBF increases in frontal and temporal cortex, basal ganglia, left hippocampal formation, and ports. Learning-specific activations were observed in conditioning as compared with pseudoconditioning in bilateral frontal cortex, left thalamus, right medial hippocampal formation, left lingual gyrus, pons, and bilateral cerebellum; decreases in rCBF were observed for bilateral temporal cortex, and in the right hemisphere in putamen, cerebellum, and the lateral aspect of hippocampal formation. Blood flow increased as the level of learning increased in the left hemisphere in caudate, hippocampal formation, fusiform gyrus, and cerebellum, and in right temporal cortex and pons. In contrast, activation in left frontal cortex decreased as learning increased. These functional imaging results implicate many of the same structures identified by previous lesion and recording studies of eyeblink conditioning in animals and humans and suggest that the same brain regions in animals and humans mediate multiple forms of associative learning that give meaning to a previously neutral stimulus.

Original languageEnglish (US)
Pages (from-to)4032-4040
Number of pages9
JournalJournal of Neuroscience
Volume16
Issue number12
DOIs
StatePublished - 1996

Keywords

  • basal ganglia
  • cerebellum
  • eyeblink conditioning
  • frontal cortex
  • hippocampus
  • learning
  • positron emission tomography (PET)

ASJC Scopus subject areas

  • Neuroscience(all)

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