Functional Neuroimaging of Deficits in Cognitive Control

Melissa Ann Mackie*, Jin Fan

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


Cognitive control is essential for efficient information processing and behavioral response under conditions of uncertainty and underlies the broad range of "executive functions." While cognitive control has often been attributed to the frontal lobes, functional neuroimaging studies have revealed the involvement of widespread cortical and subcortical regions that constitute the cognitive control network (CCN). Often, in neuropsychiatric disorders, there are reported disruptions to cognitive control and executive functions. In this chapter, we present a review and metaanalytic evidence of atypical CCN recruitment in autism spectrum disorder, schizophrenia, and major depressive disorder. These findings are discussed within the context of implications for cognitive and affective control, and social functioning in neuropsychiatric disorders.

Original languageEnglish (US)
Title of host publicationExecutive Functions in Health and Disease
PublisherElsevier Inc
Number of pages52
ISBN (Electronic)9780128037058
ISBN (Print)9780128036761
StatePublished - Jan 1 2017
Externally publishedYes


  • Autism spectrum disorder
  • Cognitive control
  • Cognitive control network
  • Executive control
  • FMRI
  • Major depressive disorder
  • Metaanalysis
  • Schizophrenia

ASJC Scopus subject areas

  • Psychology(all)

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