Functional organization of cotransmission systems: Lessons from small nervous systems

Eve Marder*, Andrew E. Christie, Valerie L. Kilman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


Small invertebrate nervous systems allow one to ask a series of questions concerning the functional roles of cotransmitters. This review outlines some of the implications of cotransmission for target selectivity in complex neuropils. We suggest the possibility that a unique constellation of cotransmitters in individual identified modulatory neurons allows a specificity of action even when peptides may act over an extended distance, and when individual modulatory substances may be released from several modulatory neurons.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalInvertebrate Neuroscience
Issue number2
StatePublished - Sep 1995


  • Crustacea
  • colocalization
  • neuroanatomy
  • neuromodulators
  • neuropeptides
  • neuropil

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience


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