Abstract
The endocannabinoid (eCB) signaling system plays a key role in short-term and long-term synaptic plasticity in brain regions involved in various neural functions ranging from action selection to appetite control. This review will explore the role of eCBs in shaping neural circuit function to regulate behaviors. In particular, we will discuss the behavioral consequences of eCB mediated long-term synaptic plasticity in different brain regions. This review brings together evidence from in vitro and ex vivo studies and points out the need for more in vivo studies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2146-2161 |
| Number of pages | 16 |
| Journal | ACS Chemical Neuroscience |
| Volume | 9 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 19 2018 |
Funding
Shana M. Augustin: 0000-0002-8123-8410 Author Contributions Both authors (S.M.A. and D.M.L.) planned, wrote, and reviewed the manuscript. Funding This work was supported by The Division of Intramural Clinical and Biological Research of the National Institute on Alcohol Abuse and Alcoholism, project # ZIA AA000416 12. Notes The authors declare no competing financial interest.
Keywords
- 2-arachidonoylglycerol
- Arachidonoylethanolamine
- cannabinoid receptors
- depolarization-induced suppression of excitation
- depolarization-induced suppression of inhibition
- long-term depression
- long-term potentiation
ASJC Scopus subject areas
- Biochemistry
- Physiology
- Cognitive Neuroscience
- Cell Biology