Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System

Shana M. Augustin, David M. Lovinger*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations

Abstract

The endocannabinoid (eCB) signaling system plays a key role in short-term and long-term synaptic plasticity in brain regions involved in various neural functions ranging from action selection to appetite control. This review will explore the role of eCBs in shaping neural circuit function to regulate behaviors. In particular, we will discuss the behavioral consequences of eCB mediated long-term synaptic plasticity in different brain regions. This review brings together evidence from in vitro and ex vivo studies and points out the need for more in vivo studies.

Original languageEnglish (US)
Pages (from-to)2146-2161
Number of pages16
JournalACS Chemical Neuroscience
Volume9
Issue number9
DOIs
StatePublished - Sep 19 2018

Keywords

  • 2-arachidonoylglycerol
  • Arachidonoylethanolamine
  • cannabinoid receptors
  • depolarization-induced suppression of excitation
  • depolarization-induced suppression of inhibition
  • long-term depression
  • long-term potentiation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Cognitive Neuroscience
  • Cell Biology

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