Functional status and clinical findings in patients with Alzheimer's disease

S. Freels*, D. Cohen, C. Eisdorfer, G. Paveza, P. Gorelick, D. J. Luchins, R. Hirschman, J. W. Ashford, P. Levy, T. Semla, H. Shaw

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


We analyzed the association of clinical findings with impaired functional status, i.e., activities of daily living (ADLs), in a sample of 240 patients diagnosed with Alzheimer's disease by NINCDS/ADRDA or DSM-III-R criteria. Logistic regression models were used to determine independent predictors of both the number of ADL impairments and number of ADL impairments characterized as moderate to severe. Two psychiatric problems, behavioral disorders and apathy, as well as a history of hypertension were significantly associated with ADL impairment independent of age, sex, race, and cognitive impairment. Behavioral disorders and apathy were also significantly associated with moderate to severe ADL impairment, but hypertension was not significant at this level.

Original languageEnglish (US)
Pages (from-to)M177-M182
JournalJournals of Gerontology
Issue number6
StatePublished - 1992

ASJC Scopus subject areas

  • Aging


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