Functional Status of Neonatal and Pediatric Patients after Extracorporeal Membrane Oxygenation

Katherine Cashen, Ron Reeder, Heidi J. Dalton, Robert A. Berg, Thomas P. Shanley, Christopher J.L. Newth, Murray M. Pollack, David Wessel, Joseph Carcillo, Rick Harrison, Michael M. Dean, Tammara Jenkins, Kathleen L. Meert*, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN)

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objectives: To describe functional status at hospital discharge for neonatal and pediatric patients treated with extracorporeal membrane oxygenation, and identify factors associated with functional status and mortality. Design: Secondary analysis of observational data collected by the Collaborative Pediatric Critical Care Research Network between December 2012 and September 2014. Setting: Eight hospitals affiliated with the Collaborative Pediatric Critical Care Research Network. Patients: Patients were less than 19 years old and treated with extracorporeal membrane oxygenation. Interventions: Functional status was evaluated among survivors using the Functional Status Scale. Total Functional Status Scale scores range from 6 to 30 and are categorized as 6-7 (good), 8-9 (mildly abnormal), 10-15 (moderately abnormal), 16-21 (severely abnormal), and greater than 21 (very severely abnormal). Measurements and Main Results: Of 514 patients, 267 (52%) were neonates (≤ 30 d old). Indication for extracorporeal membrane oxygenation was respiratory for 237 (46%), cardiac for 207 (40%), and extracorporeal cardiopulmonary resuscitation for 70 (14%). Among 282 survivors, 89 (32%) had good, 112 (40%) mildly abnormal, 67 (24%) moderately abnormal, and 14 (5%) severely or very severely abnormal function at hospital discharge. Among neonates, development of renal failure and longer hospitalization were independently associated with worse Functional Status Scale. Chronic conditions, prematurity, venoarterial extracorporeal membrane oxygenation, increased red cell transfusion in the first 24 hours of extracorporeal membrane oxygenation, and longer extracorporeal membrane oxygenation duration were independently associated with mortality. Among pediatric patients, chronic neurologic conditions, tracheostomy or home ventilator, extracorporeal cardiopulmonary resuscitation, hepatic dysfunction, and longer ICU stay were independently associated with worse Functional Status Scale. Chronic cardiac conditions, hepatic dysfunction, and neurologic or thrombotic complications were independently associated with mortality. Achieving blood lactate concentration less than or equal to 2 mmol/L during extracorporeal membrane oxygenation was independently associated with survival in both neonatal and pediatric patients. Conclusions: In this study, about half of extracorporeal membrane oxygenation patients survived with good, mildly abnormal, or moderately abnormal function at hospital discharge. Patient and extracorporeal membrane oxygenation-related factors are associated with functional status and mortality.

Original languageEnglish (US)
Pages (from-to)561-570
Number of pages10
JournalPediatric Critical Care Medicine
Volume18
Issue number6
DOIs
StatePublished - Jun 1 2017

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Extracorporeal Membrane Oxygenation
Pediatrics
Mortality
Cardiopulmonary Resuscitation
Critical Care
Survivors
Newborn Infant
Tracheostomy
Liver
Mechanical Ventilators
Neurologic Manifestations
Research
Nervous System
Renal Insufficiency
Lactic Acid
Hospitalization
Survival

Keywords

  • Extracorporeal membrane oxygenation
  • functional status

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Critical Care and Intensive Care Medicine

Cite this

Cashen, K., Reeder, R., Dalton, H. J., Berg, R. A., Shanley, T. P., Newth, C. J. L., ... for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN) (2017). Functional Status of Neonatal and Pediatric Patients after Extracorporeal Membrane Oxygenation. Pediatric Critical Care Medicine, 18(6), 561-570. https://doi.org/10.1097/PCC.0000000000001155
Cashen, Katherine ; Reeder, Ron ; Dalton, Heidi J. ; Berg, Robert A. ; Shanley, Thomas P. ; Newth, Christopher J.L. ; Pollack, Murray M. ; Wessel, David ; Carcillo, Joseph ; Harrison, Rick ; Dean, Michael M. ; Jenkins, Tammara ; Meert, Kathleen L. ; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN). / Functional Status of Neonatal and Pediatric Patients after Extracorporeal Membrane Oxygenation. In: Pediatric Critical Care Medicine. 2017 ; Vol. 18, No. 6. pp. 561-570.
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abstract = "Objectives: To describe functional status at hospital discharge for neonatal and pediatric patients treated with extracorporeal membrane oxygenation, and identify factors associated with functional status and mortality. Design: Secondary analysis of observational data collected by the Collaborative Pediatric Critical Care Research Network between December 2012 and September 2014. Setting: Eight hospitals affiliated with the Collaborative Pediatric Critical Care Research Network. Patients: Patients were less than 19 years old and treated with extracorporeal membrane oxygenation. Interventions: Functional status was evaluated among survivors using the Functional Status Scale. Total Functional Status Scale scores range from 6 to 30 and are categorized as 6-7 (good), 8-9 (mildly abnormal), 10-15 (moderately abnormal), 16-21 (severely abnormal), and greater than 21 (very severely abnormal). Measurements and Main Results: Of 514 patients, 267 (52{\%}) were neonates (≤ 30 d old). Indication for extracorporeal membrane oxygenation was respiratory for 237 (46{\%}), cardiac for 207 (40{\%}), and extracorporeal cardiopulmonary resuscitation for 70 (14{\%}). Among 282 survivors, 89 (32{\%}) had good, 112 (40{\%}) mildly abnormal, 67 (24{\%}) moderately abnormal, and 14 (5{\%}) severely or very severely abnormal function at hospital discharge. Among neonates, development of renal failure and longer hospitalization were independently associated with worse Functional Status Scale. Chronic conditions, prematurity, venoarterial extracorporeal membrane oxygenation, increased red cell transfusion in the first 24 hours of extracorporeal membrane oxygenation, and longer extracorporeal membrane oxygenation duration were independently associated with mortality. Among pediatric patients, chronic neurologic conditions, tracheostomy or home ventilator, extracorporeal cardiopulmonary resuscitation, hepatic dysfunction, and longer ICU stay were independently associated with worse Functional Status Scale. Chronic cardiac conditions, hepatic dysfunction, and neurologic or thrombotic complications were independently associated with mortality. Achieving blood lactate concentration less than or equal to 2 mmol/L during extracorporeal membrane oxygenation was independently associated with survival in both neonatal and pediatric patients. Conclusions: In this study, about half of extracorporeal membrane oxygenation patients survived with good, mildly abnormal, or moderately abnormal function at hospital discharge. Patient and extracorporeal membrane oxygenation-related factors are associated with functional status and mortality.",
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author = "Katherine Cashen and Ron Reeder and Dalton, {Heidi J.} and Berg, {Robert A.} and Shanley, {Thomas P.} and Newth, {Christopher J.L.} and Pollack, {Murray M.} and David Wessel and Joseph Carcillo and Rick Harrison and Dean, {Michael M.} and Tammara Jenkins and Meert, {Kathleen L.} and {for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN)}",
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Cashen, K, Reeder, R, Dalton, HJ, Berg, RA, Shanley, TP, Newth, CJL, Pollack, MM, Wessel, D, Carcillo, J, Harrison, R, Dean, MM, Jenkins, T, Meert, KL & for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN) 2017, 'Functional Status of Neonatal and Pediatric Patients after Extracorporeal Membrane Oxygenation', Pediatric Critical Care Medicine, vol. 18, no. 6, pp. 561-570. https://doi.org/10.1097/PCC.0000000000001155

Functional Status of Neonatal and Pediatric Patients after Extracorporeal Membrane Oxygenation. / Cashen, Katherine; Reeder, Ron; Dalton, Heidi J.; Berg, Robert A.; Shanley, Thomas P.; Newth, Christopher J.L.; Pollack, Murray M.; Wessel, David; Carcillo, Joseph; Harrison, Rick; Dean, Michael M.; Jenkins, Tammara; Meert, Kathleen L.; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).

In: Pediatric Critical Care Medicine, Vol. 18, No. 6, 01.06.2017, p. 561-570.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Functional Status of Neonatal and Pediatric Patients after Extracorporeal Membrane Oxygenation

AU - Cashen, Katherine

AU - Reeder, Ron

AU - Dalton, Heidi J.

AU - Berg, Robert A.

AU - Shanley, Thomas P.

AU - Newth, Christopher J.L.

AU - Pollack, Murray M.

AU - Wessel, David

AU - Carcillo, Joseph

AU - Harrison, Rick

AU - Dean, Michael M.

AU - Jenkins, Tammara

AU - Meert, Kathleen L.

AU - for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN)

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Objectives: To describe functional status at hospital discharge for neonatal and pediatric patients treated with extracorporeal membrane oxygenation, and identify factors associated with functional status and mortality. Design: Secondary analysis of observational data collected by the Collaborative Pediatric Critical Care Research Network between December 2012 and September 2014. Setting: Eight hospitals affiliated with the Collaborative Pediatric Critical Care Research Network. Patients: Patients were less than 19 years old and treated with extracorporeal membrane oxygenation. Interventions: Functional status was evaluated among survivors using the Functional Status Scale. Total Functional Status Scale scores range from 6 to 30 and are categorized as 6-7 (good), 8-9 (mildly abnormal), 10-15 (moderately abnormal), 16-21 (severely abnormal), and greater than 21 (very severely abnormal). Measurements and Main Results: Of 514 patients, 267 (52%) were neonates (≤ 30 d old). Indication for extracorporeal membrane oxygenation was respiratory for 237 (46%), cardiac for 207 (40%), and extracorporeal cardiopulmonary resuscitation for 70 (14%). Among 282 survivors, 89 (32%) had good, 112 (40%) mildly abnormal, 67 (24%) moderately abnormal, and 14 (5%) severely or very severely abnormal function at hospital discharge. Among neonates, development of renal failure and longer hospitalization were independently associated with worse Functional Status Scale. Chronic conditions, prematurity, venoarterial extracorporeal membrane oxygenation, increased red cell transfusion in the first 24 hours of extracorporeal membrane oxygenation, and longer extracorporeal membrane oxygenation duration were independently associated with mortality. Among pediatric patients, chronic neurologic conditions, tracheostomy or home ventilator, extracorporeal cardiopulmonary resuscitation, hepatic dysfunction, and longer ICU stay were independently associated with worse Functional Status Scale. Chronic cardiac conditions, hepatic dysfunction, and neurologic or thrombotic complications were independently associated with mortality. Achieving blood lactate concentration less than or equal to 2 mmol/L during extracorporeal membrane oxygenation was independently associated with survival in both neonatal and pediatric patients. Conclusions: In this study, about half of extracorporeal membrane oxygenation patients survived with good, mildly abnormal, or moderately abnormal function at hospital discharge. Patient and extracorporeal membrane oxygenation-related factors are associated with functional status and mortality.

AB - Objectives: To describe functional status at hospital discharge for neonatal and pediatric patients treated with extracorporeal membrane oxygenation, and identify factors associated with functional status and mortality. Design: Secondary analysis of observational data collected by the Collaborative Pediatric Critical Care Research Network between December 2012 and September 2014. Setting: Eight hospitals affiliated with the Collaborative Pediatric Critical Care Research Network. Patients: Patients were less than 19 years old and treated with extracorporeal membrane oxygenation. Interventions: Functional status was evaluated among survivors using the Functional Status Scale. Total Functional Status Scale scores range from 6 to 30 and are categorized as 6-7 (good), 8-9 (mildly abnormal), 10-15 (moderately abnormal), 16-21 (severely abnormal), and greater than 21 (very severely abnormal). Measurements and Main Results: Of 514 patients, 267 (52%) were neonates (≤ 30 d old). Indication for extracorporeal membrane oxygenation was respiratory for 237 (46%), cardiac for 207 (40%), and extracorporeal cardiopulmonary resuscitation for 70 (14%). Among 282 survivors, 89 (32%) had good, 112 (40%) mildly abnormal, 67 (24%) moderately abnormal, and 14 (5%) severely or very severely abnormal function at hospital discharge. Among neonates, development of renal failure and longer hospitalization were independently associated with worse Functional Status Scale. Chronic conditions, prematurity, venoarterial extracorporeal membrane oxygenation, increased red cell transfusion in the first 24 hours of extracorporeal membrane oxygenation, and longer extracorporeal membrane oxygenation duration were independently associated with mortality. Among pediatric patients, chronic neurologic conditions, tracheostomy or home ventilator, extracorporeal cardiopulmonary resuscitation, hepatic dysfunction, and longer ICU stay were independently associated with worse Functional Status Scale. Chronic cardiac conditions, hepatic dysfunction, and neurologic or thrombotic complications were independently associated with mortality. Achieving blood lactate concentration less than or equal to 2 mmol/L during extracorporeal membrane oxygenation was independently associated with survival in both neonatal and pediatric patients. Conclusions: In this study, about half of extracorporeal membrane oxygenation patients survived with good, mildly abnormal, or moderately abnormal function at hospital discharge. Patient and extracorporeal membrane oxygenation-related factors are associated with functional status and mortality.

KW - Extracorporeal membrane oxygenation

KW - functional status

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