Functional variation and evolution of non-coding DNA

Christine P. Bird*, Barbara Elaine Stranger, Emmanouil T. Dermitzakis

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


The focus of large genomic studies has shifted from only looking at genes and protein-coding sequences to exploring the full set of elements in each genome. The explosion of comparative sequencing data has led to an increase in methodologies, approaches and ideas on how to analyze the unknown fraction of the genome, namely the non-protein-coding fraction. The main issues relate to the discovery, evolutionary analysis and natural variation of non-coding DNA, and the parameters that prevent us from fully understanding the properties of non-coding DNA.

Original languageEnglish (US)
Pages (from-to)559-564
Number of pages6
JournalCurrent Opinion in Genetics and Development
Issue number6
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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