TY - JOUR
T1 - Functional variation and evolution of non-coding DNA
AU - Bird, Christine P.
AU - Stranger, Barbara Elaine
AU - Dermitzakis, Emmanouil T.
PY - 2006/12
Y1 - 2006/12
N2 - The focus of large genomic studies has shifted from only looking at genes and protein-coding sequences to exploring the full set of elements in each genome. The explosion of comparative sequencing data has led to an increase in methodologies, approaches and ideas on how to analyze the unknown fraction of the genome, namely the non-protein-coding fraction. The main issues relate to the discovery, evolutionary analysis and natural variation of non-coding DNA, and the parameters that prevent us from fully understanding the properties of non-coding DNA.
AB - The focus of large genomic studies has shifted from only looking at genes and protein-coding sequences to exploring the full set of elements in each genome. The explosion of comparative sequencing data has led to an increase in methodologies, approaches and ideas on how to analyze the unknown fraction of the genome, namely the non-protein-coding fraction. The main issues relate to the discovery, evolutionary analysis and natural variation of non-coding DNA, and the parameters that prevent us from fully understanding the properties of non-coding DNA.
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U2 - 10.1016/j.gde.2006.10.003
DO - 10.1016/j.gde.2006.10.003
M3 - Review article
C2 - 17055246
AN - SCOPUS:33750948552
SN - 0959-437X
VL - 16
SP - 559
EP - 564
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 6
ER -