Functionality of fibrinogen bound to PDMS

Patrick W. Whitlock, Stephen J. Clarson, Gregory S. Retzinger

Research output: Contribution to journalConference articlepeer-review

Abstract

The adsorption of fibrinogen from aqueous media, including blood plasma, to microemulsified droplets of polydimethylsiloxane (PDMS) fluid is studied. Once adsorbed, fibrinogen adheres irreversibly and is coagulable. The fibrinogen-coated particles are involved in pathologically relevant events associated with the adsorption of fibrinogen in hydrophobic surfaces. These events include acute inflammation, granuloma formation, immune adjuvancy and particle dissemination. The involvement of fibrinogen in pathologies associated with these hydrophobic particulate surfaces may also exist at the surface of another hydrophobic material.

Original languageEnglish (US)
Pages (from-to)770-771
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume40
Issue number2
StatePublished - Aug 1999

ASJC Scopus subject areas

  • Polymers and Plastics

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