The adsorption of fibrinogen from aqueous media, including blood plasma, to microemulsified droplets of polydimethylsiloxane (PDMS) fluid is studied. Once adsorbed, fibrinogen adheres irreversibly and is coagulable. The fibrinogen-coated particles are involved in pathologically relevant events associated with the adsorption of fibrinogen in hydrophobic surfaces. These events include acute inflammation, granuloma formation, immune adjuvancy and particle dissemination. The involvement of fibrinogen in pathologies associated with these hydrophobic particulate surfaces may also exist at the surface of another hydrophobic material.
|Original language||English (US)|
|Number of pages||2|
|Journal||American Chemical Society, Polymer Preprints, Division of Polymer Chemistry|
|State||Published - Aug 1 1999|
ASJC Scopus subject areas
- Polymers and Plastics