TY - JOUR
T1 - Functionality of fibrinogen bound to PDMS
AU - Whitlock, Patrick W.
AU - Clarson, Stephen J.
AU - Retzinger, Gregory S.
PY - 1999/8/1
Y1 - 1999/8/1
N2 - The adsorption of fibrinogen from aqueous media, including blood plasma, to microemulsified droplets of polydimethylsiloxane (PDMS) fluid is studied. Once adsorbed, fibrinogen adheres irreversibly and is coagulable. The fibrinogen-coated particles are involved in pathologically relevant events associated with the adsorption of fibrinogen in hydrophobic surfaces. These events include acute inflammation, granuloma formation, immune adjuvancy and particle dissemination. The involvement of fibrinogen in pathologies associated with these hydrophobic particulate surfaces may also exist at the surface of another hydrophobic material.
AB - The adsorption of fibrinogen from aqueous media, including blood plasma, to microemulsified droplets of polydimethylsiloxane (PDMS) fluid is studied. Once adsorbed, fibrinogen adheres irreversibly and is coagulable. The fibrinogen-coated particles are involved in pathologically relevant events associated with the adsorption of fibrinogen in hydrophobic surfaces. These events include acute inflammation, granuloma formation, immune adjuvancy and particle dissemination. The involvement of fibrinogen in pathologies associated with these hydrophobic particulate surfaces may also exist at the surface of another hydrophobic material.
UR - http://www.scopus.com/inward/record.url?scp=0032626246&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032626246&partnerID=8YFLogxK
M3 - Conference article
AN - SCOPUS:0032626246
SN - 0032-3934
VL - 40
SP - 770
EP - 771
JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
IS - 2
ER -