Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration

Ebrahim Afshinnekoo; Ryan T. Scott; Matthew J. MacKay; Eloise Pariset; Egle Cekanaviciute; Richard Barker; Simon Gilroy; Duane Hassane; Scott M. Smith; Sara R. Zwart; Mayra Nelman-Gonzalez; Brian E. Crucian; Sergey A. Ponomarev; Oleg I. Orlov; Dai Shiba; Masafumi Muratani; Masayuki Yamamoto; Stephanie E. Richards; Parag A. Vaishampayan; Cem Meydan; Jonathan Foox; Jacqueline Myrrhe; Eric Istasse; Nitin Singh; Kasthuri Venkateswaran; Jessica A. Keune; Hami E. Ray; Mathias Basner; Jack Miller; Martha Hotz Vitaterna; Deanne M. Taylor; Douglas Wallace; Kathleen Rubins; Susan M. Bailey; Peter Grabham; Sylvain V. Costes; Christopher E. Mason; Afshin Beheshti

doi:10.1016/j.cell.2020.10.050

Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration

Ebrahim Afshinnekoo, Ryan T. Scott, Matthew J. MacKay, Eloise Pariset, Egle Cekanaviciute, Richard Barker, Simon Gilroy, Duane Hassane, Scott M. Smith, Sara R. Zwart, Mayra Nelman-Gonzalez, Brian E. Crucian, Sergey A. Ponomarev, Oleg I. Orlov, Dai Shiba, Masafumi Muratani, Masayuki Yamamoto, Stephanie E. Richards, Parag A. Vaishampayan, Cem MeydanJonathan Foox, Jacqueline Myrrhe, Eric Istasse, Nitin Singh, Kasthuri Venkateswaran, Jessica A. Keune, Hami E. Ray, Mathias Basner, Jack Miller, Martha Hotz Vitaterna, Deanne M. Taylor, Douglas Wallace, Kathleen Rubins, Susan M. Bailey^*, Peter Grabham, Sylvain V. Costes, Christopher E. Mason, Afshin Beheshti

^*Corresponding author for this work

CSCB - Center for Sleep and Circadian Biology

Research output: Contribution to journal › Review article › peer-review

271 Scopus citations

Abstract

An international group of spaceflight researchers detail how spaceflight affects human biology from the molecular to physiological level and identify key challenges for making space exploration compatible with human health.

Original language	English (US)
Pages (from-to)	1162-1184
Number of pages	23
Journal	Cell
Volume	183
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2020.10.050
State	Published - Nov 25 2020

Funding

Special thanks to Drs. Craig Kundrot and Thomas Zurbuchen for their valuable input regarding this manuscript. Thanks also to the various stakeholders in providing guidance and compiling the Data and Biospecimens table and box: Nicholas Meyer of the NASA Human Research Program's Space Radiation Element at NASA JSC; Rebecca Klotz from the NASA Space Biology Biospecimen Sharing Program at NASA ARC; Danielle Lopez, Martha del Alto, and Alison French from the NASA Ames Life Sciences Data Archive; Thomas Bristow of the Exobiology Branch, Space Science & Astrobiology Division at NASA ARC; and Barbara Lafuente of the SETI Institute in Mountain View, CA. Thanks also to Graham Mackintosh, Artificial Intelligence Consultant at NASA ARC; Christopher Dateo of Exobiology Branch, Space Science & Astrobiology Division at ARC; and Melissa Kirven-Brooks of Astrobiology at ARC. Lastly, thank you to the various organizations at NASA for their overall support: Space Biology Program, Science Mission Directorate, Biological and Physical Sciences Division; Human Research Program, Human Exploration and Operations Mission Directorate; the GeneLab team at ARC; the XSEDE Supercomputing Center and the Scientific Computing Unit (SCU) at WCM; and the LSDA and LSAH teams at JSC. Support was provided by NASA: NNX14AH51G (all Twins Study principal investigators [PIs]; NNX14AB02G and 80NSSC19K0434 (S.M.B.); NNX14AH50G, NNX17AB26G, and 19_HCBPSR_2-0067. Support was also provided by the NIH (R01CA249054, R01AI151059, and R01MH117406 to C.E.M.). A.B. was supported by NASA grant 16-ROSBFP_GL-0005: NNH16ZTT001N-FG Appendix G: Solicitation of Proposals for Flight and Ground Space Biology Research (Award Number: 80NSSC19K0883) and the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404). S.P. and O.O. were supported by the program of fundamental research (themes 64.1; 65.1) of the IBMP. S.V.C. and E.C. are funded by NASA Human Research Program grants NNJ16HP24I (S.V.C.) and 80JSC018N001 (E.C.) and E.P. by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A. P.G. is funded by Human Research Program grant 80NSS18K1492. Special thanks to Drs. Craig Kundrot and Thomas Zurbuchen for their valuable input regarding this manuscript. Thanks also to the various stakeholders in providing guidance and compiling the Data and Biospecimens table and box: Nicholas Meyer of the NASA Human Research Program\u2019s Space Radiation Element at NASA JSC; Rebecca Klotz from the NASA Space Biology Biospecimen Sharing Program at NASA ARC; Danielle Lopez, Martha del Alto, and Alison French from the NASA Ames Life Sciences Data Archive; Thomas Bristow of the Exobiology Branch, Space Science & Astrobiology Division at NASA ARC; and Barbara Lafuente of the SETI Institute in Mountain View, CA. Thanks also to Graham Mackintosh, Artificial Intelligence Consultant at NASA ARC; Christopher Dateo of Exobiology Branch, Space Science & Astrobiology Division at ARC; and Melissa Kirven-Brooks of Astrobiology at ARC. Lastly, thank you to the various organizations at NASA for their overall support: Space Biology Program, Science Mission Directorate, Biological and Physical Sciences Division; Human Research Program, Human Exploration and Operations Mission Directorate; the GeneLab team at ARC; the XSEDE Supercomputing Center and the Scientific Computing Unit (SCU) at WCM; and the LSDA and LSAH teams at JSC. Support was provided by NASA : NNX14AH51G (all Twins Study principal investigators [PIs]; NNX14AB02G and 80NSSC19K0434 (S.M.B.); NNX14AH50G , NNX17AB26G , and 19_HCBPSR_2-0067 . Support was also provided by the NIH ( R01CA249054 , R01AI151059 , and R01MH117406 to C.E.M.). A.B. was supported by NASA grant 16-ROSBFP_GL-0005 : NNH16ZTT001N-FG Appendix G : Solicitation of Proposals for Flight and Ground Space Biology Research (Award Number: 80NSSC19K0883 ) and the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404). S.P. and O.O. were supported by the program of fundamental research (themes 64.1; 65.1) of the IBMP. S.V.C. and E.C. are funded by NASA Human Research Program grants NNJ16HP24I (S.V.C.) and 80JSC018N001 (E.C.) and E.P. by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A . P.G. is funded by Human Research Program grant 80NSS18K1492 .

Keywords

aerospace medicine
DNA damage
epigenetic
microbiome
mitochondria
multi-omics
oxidative stress
space biology
spaceflight
telomere

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.cell.2020.10.050

Cite this

Afshinnekoo, E., Scott, R. T., MacKay, M. J., Pariset, E., Cekanaviciute, E., Barker, R., Gilroy, S., Hassane, D., Smith, S. M., Zwart, S. R., Nelman-Gonzalez, M., Crucian, B. E., Ponomarev, S. A., Orlov, O. I., Shiba, D., Muratani, M., Yamamoto, M., Richards, S. E., Vaishampayan, P. A., ... Beheshti, A. (2020). Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration. Cell, 183(5), 1162-1184. https://doi.org/10.1016/j.cell.2020.10.050

@article{4928e128e9a144cdb80a9f595b125cf3,

title = "Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration",

abstract = "An international group of spaceflight researchers detail how spaceflight affects human biology from the molecular to physiological level and identify key challenges for making space exploration compatible with human health.",

keywords = "aerospace medicine, DNA damage, epigenetic, microbiome, mitochondria, multi-omics, oxidative stress, space biology, spaceflight, telomere",

author = "Ebrahim Afshinnekoo and Scott, {Ryan T.} and MacKay, {Matthew J.} and Eloise Pariset and Egle Cekanaviciute and Richard Barker and Simon Gilroy and Duane Hassane and Smith, {Scott M.} and Zwart, {Sara R.} and Mayra Nelman-Gonzalez and Crucian, {Brian E.} and Ponomarev, {Sergey A.} and Orlov, {Oleg I.} and Dai Shiba and Masafumi Muratani and Masayuki Yamamoto and Richards, {Stephanie E.} and Vaishampayan, {Parag A.} and Cem Meydan and Jonathan Foox and Jacqueline Myrrhe and Eric Istasse and Nitin Singh and Kasthuri Venkateswaran and Keune, {Jessica A.} and Ray, {Hami E.} and Mathias Basner and Jack Miller and Vitaterna, {Martha Hotz} and Taylor, {Deanne M.} and Douglas Wallace and Kathleen Rubins and Bailey, {Susan M.} and Peter Grabham and Costes, {Sylvain V.} and Mason, {Christopher E.} and Afshin Beheshti",

note = "Funding Information: Special thanks to Drs. Craig Kundrot and Thomas Zurbuchen for their valuable input regarding this manuscript. Thanks also to the various stakeholders in providing guidance and compiling the Data and Biospecimens table and box: Nicholas Meyer of the NASA Human Research Program's Space Radiation Element at NASA JSC; Rebecca Klotz from the NASA Space Biology Biospecimen Sharing Program at NASA ARC; Danielle Lopez, Martha del Alto, and Alison French from the NASA Ames Life Sciences Data Archive; Thomas Bristow of the Exobiology Branch, Space Science & Astrobiology Division at NASA ARC; and Barbara Lafuente of the SETI Institute in Mountain View, CA. Thanks also to Graham Mackintosh, Artificial Intelligence Consultant at NASA ARC; Christopher Dateo of Exobiology Branch, Space Science & Astrobiology Division at ARC; and Melissa Kirven-Brooks of Astrobiology at ARC. Lastly, thank you to the various organizations at NASA for their overall support: Space Biology Program, Science Mission Directorate, Biological and Physical Sciences Division; Human Research Program, Human Exploration and Operations Mission Directorate; the GeneLab team at ARC; the XSEDE Supercomputing Center and the Scientific Computing Unit (SCU) at WCM; and the LSDA and LSAH teams at JSC. Support was provided by NASA: NNX14AH51G (all Twins Study principal investigators [PIs]; NNX14AB02G and 80NSSC19K0434 (S.M.B.); NNX14AH50G, NNX17AB26G, and 19_HCBPSR_2-0067. Support was also provided by the NIH (R01CA249054, R01AI151059, and R01MH117406 to C.E.M.). A.B. was supported by NASA grant 16-ROSBFP_GL-0005: NNH16ZTT001N-FG Appendix G: Solicitation of Proposals for Flight and Ground Space Biology Research (Award Number: 80NSSC19K0883) and the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404). S.P. and O.O. were supported by the program of fundamental research (themes 64.1; 65.1) of the IBMP. S.V.C. and E.C. are funded by NASA Human Research Program grants NNJ16HP24I (S.V.C.) and 80JSC018N001 (E.C.) and E.P. by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A. P.G. is funded by Human Research Program grant 80NSS18K1492. Funding Information: Special thanks to Drs. Craig Kundrot and Thomas Zurbuchen for their valuable input regarding this manuscript. Thanks also to the various stakeholders in providing guidance and compiling the Data and Biospecimens table and box: Nicholas Meyer of the NASA Human Research Program{\textquoteright}s Space Radiation Element at NASA JSC; Rebecca Klotz from the NASA Space Biology Biospecimen Sharing Program at NASA ARC; Danielle Lopez, Martha del Alto, and Alison French from the NASA Ames Life Sciences Data Archive; Thomas Bristow of the Exobiology Branch, Space Science & Astrobiology Division at NASA ARC; and Barbara Lafuente of the SETI Institute in Mountain View, CA. Thanks also to Graham Mackintosh, Artificial Intelligence Consultant at NASA ARC; Christopher Dateo of Exobiology Branch, Space Science & Astrobiology Division at ARC; and Melissa Kirven-Brooks of Astrobiology at ARC. Lastly, thank you to the various organizations at NASA for their overall support: Space Biology Program, Science Mission Directorate, Biological and Physical Sciences Division; Human Research Program, Human Exploration and Operations Mission Directorate; the GeneLab team at ARC; the XSEDE Supercomputing Center and the Scientific Computing Unit (SCU) at WCM; and the LSDA and LSAH teams at JSC. Support was provided by NASA : NNX14AH51G (all Twins Study principal investigators [PIs]; NNX14AB02G and 80NSSC19K0434 (S.M.B.); NNX14AH50G , NNX17AB26G , and 19_HCBPSR_2-0067 . Support was also provided by the NIH ( R01CA249054 , R01AI151059 , and R01MH117406 to C.E.M.). A.B. was supported by NASA grant 16-ROSBFP_GL-0005 : NNH16ZTT001N-FG Appendix G : Solicitation of Proposals for Flight and Ground Space Biology Research (Award Number: 80NSSC19K0883 ) and the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404). S.P. and O.O. were supported by the program of fundamental research (themes 64.1; 65.1) of the IBMP. S.V.C. and E.C. are funded by NASA Human Research Program grants NNJ16HP24I (S.V.C.) and 80JSC018N001 (E.C.) and E.P. by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A . P.G. is funded by Human Research Program grant 80NSS18K1492 . Publisher Copyright: {\textcopyright} 2020 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2020",

month = nov,

day = "25",

doi = "10.1016/j.cell.2020.10.050",

language = "English (US)",

volume = "183",

pages = "1162--1184",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "5",

}

Afshinnekoo, E, Scott, RT, MacKay, MJ, Pariset, E, Cekanaviciute, E, Barker, R, Gilroy, S, Hassane, D, Smith, SM, Zwart, SR, Nelman-Gonzalez, M, Crucian, BE, Ponomarev, SA, Orlov, OI, Shiba, D, Muratani, M, Yamamoto, M, Richards, SE, Vaishampayan, PA, Meydan, C, Foox, J, Myrrhe, J, Istasse, E, Singh, N, Venkateswaran, K, Keune, JA, Ray, HE, Basner, M, Miller, J, Vitaterna, MH, Taylor, DM, Wallace, D, Rubins, K, Bailey, SM, Grabham, P, Costes, SV, Mason, CE & Beheshti, A 2020, 'Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration', Cell, vol. 183, no. 5, pp. 1162-1184. https://doi.org/10.1016/j.cell.2020.10.050

TY - JOUR

T1 - Fundamental Biological Features of Spaceflight

T2 - Advancing the Field to Enable Deep-Space Exploration

AU - Afshinnekoo, Ebrahim

AU - Scott, Ryan T.

AU - MacKay, Matthew J.

AU - Pariset, Eloise

AU - Cekanaviciute, Egle

AU - Barker, Richard

AU - Gilroy, Simon

AU - Hassane, Duane

AU - Smith, Scott M.

AU - Zwart, Sara R.

AU - Nelman-Gonzalez, Mayra

AU - Crucian, Brian E.

AU - Ponomarev, Sergey A.

AU - Orlov, Oleg I.

AU - Shiba, Dai

AU - Muratani, Masafumi

AU - Yamamoto, Masayuki

AU - Richards, Stephanie E.

AU - Vaishampayan, Parag A.

AU - Meydan, Cem

AU - Foox, Jonathan

AU - Myrrhe, Jacqueline

AU - Istasse, Eric

AU - Singh, Nitin

AU - Venkateswaran, Kasthuri

AU - Keune, Jessica A.

AU - Ray, Hami E.

AU - Basner, Mathias

AU - Miller, Jack

AU - Vitaterna, Martha Hotz

AU - Taylor, Deanne M.

AU - Wallace, Douglas

AU - Rubins, Kathleen

AU - Bailey, Susan M.

AU - Grabham, Peter

AU - Costes, Sylvain V.

AU - Mason, Christopher E.

AU - Beheshti, Afshin

N1 - Funding Information: Special thanks to Drs. Craig Kundrot and Thomas Zurbuchen for their valuable input regarding this manuscript. Thanks also to the various stakeholders in providing guidance and compiling the Data and Biospecimens table and box: Nicholas Meyer of the NASA Human Research Program's Space Radiation Element at NASA JSC; Rebecca Klotz from the NASA Space Biology Biospecimen Sharing Program at NASA ARC; Danielle Lopez, Martha del Alto, and Alison French from the NASA Ames Life Sciences Data Archive; Thomas Bristow of the Exobiology Branch, Space Science & Astrobiology Division at NASA ARC; and Barbara Lafuente of the SETI Institute in Mountain View, CA. Thanks also to Graham Mackintosh, Artificial Intelligence Consultant at NASA ARC; Christopher Dateo of Exobiology Branch, Space Science & Astrobiology Division at ARC; and Melissa Kirven-Brooks of Astrobiology at ARC. Lastly, thank you to the various organizations at NASA for their overall support: Space Biology Program, Science Mission Directorate, Biological and Physical Sciences Division; Human Research Program, Human Exploration and Operations Mission Directorate; the GeneLab team at ARC; the XSEDE Supercomputing Center and the Scientific Computing Unit (SCU) at WCM; and the LSDA and LSAH teams at JSC. Support was provided by NASA: NNX14AH51G (all Twins Study principal investigators [PIs]; NNX14AB02G and 80NSSC19K0434 (S.M.B.); NNX14AH50G, NNX17AB26G, and 19_HCBPSR_2-0067. Support was also provided by the NIH (R01CA249054, R01AI151059, and R01MH117406 to C.E.M.). A.B. was supported by NASA grant 16-ROSBFP_GL-0005: NNH16ZTT001N-FG Appendix G: Solicitation of Proposals for Flight and Ground Space Biology Research (Award Number: 80NSSC19K0883) and the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404). S.P. and O.O. were supported by the program of fundamental research (themes 64.1; 65.1) of the IBMP. S.V.C. and E.C. are funded by NASA Human Research Program grants NNJ16HP24I (S.V.C.) and 80JSC018N001 (E.C.) and E.P. by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A. P.G. is funded by Human Research Program grant 80NSS18K1492. Funding Information: Special thanks to Drs. Craig Kundrot and Thomas Zurbuchen for their valuable input regarding this manuscript. Thanks also to the various stakeholders in providing guidance and compiling the Data and Biospecimens table and box: Nicholas Meyer of the NASA Human Research Program’s Space Radiation Element at NASA JSC; Rebecca Klotz from the NASA Space Biology Biospecimen Sharing Program at NASA ARC; Danielle Lopez, Martha del Alto, and Alison French from the NASA Ames Life Sciences Data Archive; Thomas Bristow of the Exobiology Branch, Space Science & Astrobiology Division at NASA ARC; and Barbara Lafuente of the SETI Institute in Mountain View, CA. Thanks also to Graham Mackintosh, Artificial Intelligence Consultant at NASA ARC; Christopher Dateo of Exobiology Branch, Space Science & Astrobiology Division at ARC; and Melissa Kirven-Brooks of Astrobiology at ARC. Lastly, thank you to the various organizations at NASA for their overall support: Space Biology Program, Science Mission Directorate, Biological and Physical Sciences Division; Human Research Program, Human Exploration and Operations Mission Directorate; the GeneLab team at ARC; the XSEDE Supercomputing Center and the Scientific Computing Unit (SCU) at WCM; and the LSDA and LSAH teams at JSC. Support was provided by NASA : NNX14AH51G (all Twins Study principal investigators [PIs]; NNX14AB02G and 80NSSC19K0434 (S.M.B.); NNX14AH50G , NNX17AB26G , and 19_HCBPSR_2-0067 . Support was also provided by the NIH ( R01CA249054 , R01AI151059 , and R01MH117406 to C.E.M.). A.B. was supported by NASA grant 16-ROSBFP_GL-0005 : NNH16ZTT001N-FG Appendix G : Solicitation of Proposals for Flight and Ground Space Biology Research (Award Number: 80NSSC19K0883 ) and the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404). S.P. and O.O. were supported by the program of fundamental research (themes 64.1; 65.1) of the IBMP. S.V.C. and E.C. are funded by NASA Human Research Program grants NNJ16HP24I (S.V.C.) and 80JSC018N001 (E.C.) and E.P. by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A . P.G. is funded by Human Research Program grant 80NSS18K1492 . Publisher Copyright: © 2020 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2020/11/25

Y1 - 2020/11/25

N2 - An international group of spaceflight researchers detail how spaceflight affects human biology from the molecular to physiological level and identify key challenges for making space exploration compatible with human health.

AB - An international group of spaceflight researchers detail how spaceflight affects human biology from the molecular to physiological level and identify key challenges for making space exploration compatible with human health.

KW - aerospace medicine

KW - DNA damage

KW - epigenetic

KW - microbiome

KW - mitochondria

KW - multi-omics

KW - oxidative stress

KW - space biology

KW - spaceflight

KW - telomere

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Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration

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