Fungal metabolite analysis in genomics and phenomics

Michael C. Jewett*, Gerald Hofmann, Jens Nielsen

*Corresponding author for this work

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Metabolomics consists of strategies to quantitatively identify cellular metabolites and to understand how trafficking of these biochemical messengers through the metabolic network influences phenotype. The application of metabolomics to fungi has been strongly pursued because these organisms are widely used for the production of chemicals, are well known for their diverse metabolic landscape and serve as excellent eukaryotic model organisms for studying metabolism and systems biology. Within the context of fungal systems, recent progress has been made in the development of analytical tools and mathematical strategies used in metabolite analysis that have enhanced our ability to crack the code underpinning the cellular inventory, regulatory schemes and communication mechanisms that dictate cellular function. Metabolomics has played a key role in functional genomics and strain classification.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalCurrent Opinion in Biotechnology
Volume17
Issue number2
DOIs
StatePublished - Apr 1 2006

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ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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