@article{30eb426bf434481f920f1a08a9d18f72,
title = "Furanodiene induces extrinsic and intrinsic apoptosis in doxorubicin-resistant MCF-7 breast cancer cells via NF-κB-independent mechanism",
abstract = "Chemotherapy is used as a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur when chemotherapy is used clinically, resulting in poor prognosis and recurrence. Currently, Chinese medicine may provide insight into the design of new therapies to overcome chemo-resistance. Furanodiene, as a heat-sensitive sesquiterpene, is isolated from the essential oil of Rhizoma Curcumae. Even though mounting evidence claiming that furanodiene possesses anti-cancer activities in various types of cancers, the underlying mechanisms against chemo-resistant cancer are not fully clear. Our study found that furanodiene could display anti-cancer effects by inhibiting cell viability, inducing cell cytotoxicity, and suppressing cell proliferation in doxorubicin-resistant MCF-7 breast cancer cells. Furthermore, furanodiene preferentially causes apoptosis by interfering with intrinsic/extrinsic-dependent and NF-?B-independent pathways in doxorubicin-resistant MCF-7 cells. These observations also prompt that furanodiene may be developed as a promising natural product for multidrug-resistant cancer therapy in the future.",
keywords = "Breast cancer, Cell apoptosis, Furanodiene, Intrinsic/extrinsic apoptosis, Multidrug resistance, NF-κB",
author = "Zhong, {Zhang Feng} and Yu, {Hai Bing} and Wang, {Chun Ming} and Qiang, {Wen An} and Wang, {Sheng Peng} and Zhang, {Jin Ming} and Hua Yu and Liao Cui and Tie Wu and Li, {De Qiang} and Wang, {Yi Tao}",
note = "Funding Information: This study was supported by the Macao Science and Technology Development Fund (080/2016/A2 and 126/2016/A3), the Research Fund of University of Macau (MYRG2016-00143-ICMS-QRCM and MYRG2016-00031-ICMS-QRCM), the National Natural Science Foundation of China (Nos: 81603066, 81470170, and 81273166), the International Technology Cooperation Projects of Dongguan (20135081520017), the Features Innovative Projects of Key Platform and Major Scientific Research Project of Universities in Guangdong Province (2015KTSCX048), and the Technology Plan Projects of Medical and Health Science in Dongguan City (201605101290). Wen-An Qiang was partially supported by NU-PSOC (U54 CA193419) and Robert H. Lurie Comprehensive Cancer Center OncoSET initiatives at the Northwestern University. We also thank Stacy Ann Kujawa in Northwestern University Feinberg School of Medicine for critical proofreading of the manuscript. Publisher Copyright: {\textcopyright} 2017 Zhong, Yu, Wang, Qiang, Wang, Zhang, Yu, Cui, Wu, Li and Wang.",
year = "2017",
month = sep,
day = "14",
doi = "10.3389/fphar.2017.00648",
language = "English (US)",
volume = "8",
journal = "Frontiers in Pharmacology",
issn = "1663-9812",
publisher = "Frontiers Media S. A.",
number = "SEP",
}
