Furanodiene induces extrinsic and intrinsic apoptosis in doxorubicin-resistant MCF-7 breast cancer cells via NF-κB-independent mechanism

Zhang Feng Zhong; Hai Bing Yu; Chun Ming Wang; Wen An Qiang; Sheng Peng Wang; Jin Ming Zhang; Hua Yu; Liao Cui; Tie Wu; De Qiang Li; Yi Tao Wang

doi:10.3389/fphar.2017.00648

Furanodiene induces extrinsic and intrinsic apoptosis in doxorubicin-resistant MCF-7 breast cancer cells via NF-κB-independent mechanism

Zhang Feng Zhong, Hai Bing Yu, Chun Ming Wang, Wen An Qiang, Sheng Peng Wang, Jin Ming Zhang, Hua Yu, Liao Cui, Tie Wu, De Qiang Li, Yi Tao Wang^*

^*Corresponding author for this work

CLP - Chemistry of Life Processes Institute

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Chemotherapy is used as a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur when chemotherapy is used clinically, resulting in poor prognosis and recurrence. Currently, Chinese medicine may provide insight into the design of new therapies to overcome chemo-resistance. Furanodiene, as a heat-sensitive sesquiterpene, is isolated from the essential oil of Rhizoma Curcumae. Even though mounting evidence claiming that furanodiene possesses anti-cancer activities in various types of cancers, the underlying mechanisms against chemo-resistant cancer are not fully clear. Our study found that furanodiene could display anti-cancer effects by inhibiting cell viability, inducing cell cytotoxicity, and suppressing cell proliferation in doxorubicin-resistant MCF-7 breast cancer cells. Furthermore, furanodiene preferentially causes apoptosis by interfering with intrinsic/extrinsic-dependent and NF-?B-independent pathways in doxorubicin-resistant MCF-7 cells. These observations also prompt that furanodiene may be developed as a promising natural product for multidrug-resistant cancer therapy in the future.

Original language	English (US)
Article number	648
Journal	Frontiers in Pharmacology
Volume	8
Issue number	SEP
DOIs	https://doi.org/10.3389/fphar.2017.00648
State	Published - Sep 14 2017

Funding

This study was supported by the Macao Science and Technology Development Fund (080/2016/A2 and 126/2016/A3), the Research Fund of University of Macau (MYRG2016-00143-ICMS-QRCM and MYRG2016-00031-ICMS-QRCM), the National Natural Science Foundation of China (Nos: 81603066, 81470170, and 81273166), the International Technology Cooperation Projects of Dongguan (20135081520017), the Features Innovative Projects of Key Platform and Major Scientific Research Project of Universities in Guangdong Province (2015KTSCX048), and the Technology Plan Projects of Medical and Health Science in Dongguan City (201605101290). Wen-An Qiang was partially supported by NU-PSOC (U54 CA193419) and Robert H. Lurie Comprehensive Cancer Center OncoSET initiatives at the Northwestern University. We also thank Stacy Ann Kujawa in Northwestern University Feinberg School of Medicine for critical proofreading of the manuscript.

Keywords

Breast cancer
Cell apoptosis
Furanodiene
Intrinsic/extrinsic apoptosis
Multidrug resistance
NF-κB

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fphar.2017.00648

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@article{30eb426bf434481f920f1a08a9d18f72,

title = "Furanodiene induces extrinsic and intrinsic apoptosis in doxorubicin-resistant MCF-7 breast cancer cells via NF-κB-independent mechanism",

abstract = "Chemotherapy is used as a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur when chemotherapy is used clinically, resulting in poor prognosis and recurrence. Currently, Chinese medicine may provide insight into the design of new therapies to overcome chemo-resistance. Furanodiene, as a heat-sensitive sesquiterpene, is isolated from the essential oil of Rhizoma Curcumae. Even though mounting evidence claiming that furanodiene possesses anti-cancer activities in various types of cancers, the underlying mechanisms against chemo-resistant cancer are not fully clear. Our study found that furanodiene could display anti-cancer effects by inhibiting cell viability, inducing cell cytotoxicity, and suppressing cell proliferation in doxorubicin-resistant MCF-7 breast cancer cells. Furthermore, furanodiene preferentially causes apoptosis by interfering with intrinsic/extrinsic-dependent and NF-?B-independent pathways in doxorubicin-resistant MCF-7 cells. These observations also prompt that furanodiene may be developed as a promising natural product for multidrug-resistant cancer therapy in the future.",

keywords = "Breast cancer, Cell apoptosis, Furanodiene, Intrinsic/extrinsic apoptosis, Multidrug resistance, NF-κB",

author = "Zhong, {Zhang Feng} and Yu, {Hai Bing} and Wang, {Chun Ming} and Qiang, {Wen An} and Wang, {Sheng Peng} and Zhang, {Jin Ming} and Hua Yu and Liao Cui and Tie Wu and Li, {De Qiang} and Wang, {Yi Tao}",

note = "Funding Information: This study was supported by the Macao Science and Technology Development Fund (080/2016/A2 and 126/2016/A3), the Research Fund of University of Macau (MYRG2016-00143-ICMS-QRCM and MYRG2016-00031-ICMS-QRCM), the National Natural Science Foundation of China (Nos: 81603066, 81470170, and 81273166), the International Technology Cooperation Projects of Dongguan (20135081520017), the Features Innovative Projects of Key Platform and Major Scientific Research Project of Universities in Guangdong Province (2015KTSCX048), and the Technology Plan Projects of Medical and Health Science in Dongguan City (201605101290). Wen-An Qiang was partially supported by NU-PSOC (U54 CA193419) and Robert H. Lurie Comprehensive Cancer Center OncoSET initiatives at the Northwestern University. We also thank Stacy Ann Kujawa in Northwestern University Feinberg School of Medicine for critical proofreading of the manuscript. Publisher Copyright: {\textcopyright} 2017 Zhong, Yu, Wang, Qiang, Wang, Zhang, Yu, Cui, Wu, Li and Wang.",

year = "2017",

month = sep,

day = "14",

doi = "10.3389/fphar.2017.00648",

language = "English (US)",

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journal = "Frontiers in Pharmacology",

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T1 - Furanodiene induces extrinsic and intrinsic apoptosis in doxorubicin-resistant MCF-7 breast cancer cells via NF-κB-independent mechanism

AU - Zhong, Zhang Feng

AU - Yu, Hai Bing

AU - Wang, Chun Ming

AU - Qiang, Wen An

AU - Wang, Sheng Peng

AU - Zhang, Jin Ming

AU - Yu, Hua

AU - Cui, Liao

AU - Wu, Tie

AU - Li, De Qiang

AU - Wang, Yi Tao

N1 - Funding Information: This study was supported by the Macao Science and Technology Development Fund (080/2016/A2 and 126/2016/A3), the Research Fund of University of Macau (MYRG2016-00143-ICMS-QRCM and MYRG2016-00031-ICMS-QRCM), the National Natural Science Foundation of China (Nos: 81603066, 81470170, and 81273166), the International Technology Cooperation Projects of Dongguan (20135081520017), the Features Innovative Projects of Key Platform and Major Scientific Research Project of Universities in Guangdong Province (2015KTSCX048), and the Technology Plan Projects of Medical and Health Science in Dongguan City (201605101290). Wen-An Qiang was partially supported by NU-PSOC (U54 CA193419) and Robert H. Lurie Comprehensive Cancer Center OncoSET initiatives at the Northwestern University. We also thank Stacy Ann Kujawa in Northwestern University Feinberg School of Medicine for critical proofreading of the manuscript. Publisher Copyright: © 2017 Zhong, Yu, Wang, Qiang, Wang, Zhang, Yu, Cui, Wu, Li and Wang.

PY - 2017/9/14

Y1 - 2017/9/14

N2 - Chemotherapy is used as a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur when chemotherapy is used clinically, resulting in poor prognosis and recurrence. Currently, Chinese medicine may provide insight into the design of new therapies to overcome chemo-resistance. Furanodiene, as a heat-sensitive sesquiterpene, is isolated from the essential oil of Rhizoma Curcumae. Even though mounting evidence claiming that furanodiene possesses anti-cancer activities in various types of cancers, the underlying mechanisms against chemo-resistant cancer are not fully clear. Our study found that furanodiene could display anti-cancer effects by inhibiting cell viability, inducing cell cytotoxicity, and suppressing cell proliferation in doxorubicin-resistant MCF-7 breast cancer cells. Furthermore, furanodiene preferentially causes apoptosis by interfering with intrinsic/extrinsic-dependent and NF-?B-independent pathways in doxorubicin-resistant MCF-7 cells. These observations also prompt that furanodiene may be developed as a promising natural product for multidrug-resistant cancer therapy in the future.

AB - Chemotherapy is used as a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur when chemotherapy is used clinically, resulting in poor prognosis and recurrence. Currently, Chinese medicine may provide insight into the design of new therapies to overcome chemo-resistance. Furanodiene, as a heat-sensitive sesquiterpene, is isolated from the essential oil of Rhizoma Curcumae. Even though mounting evidence claiming that furanodiene possesses anti-cancer activities in various types of cancers, the underlying mechanisms against chemo-resistant cancer are not fully clear. Our study found that furanodiene could display anti-cancer effects by inhibiting cell viability, inducing cell cytotoxicity, and suppressing cell proliferation in doxorubicin-resistant MCF-7 breast cancer cells. Furthermore, furanodiene preferentially causes apoptosis by interfering with intrinsic/extrinsic-dependent and NF-?B-independent pathways in doxorubicin-resistant MCF-7 cells. These observations also prompt that furanodiene may be developed as a promising natural product for multidrug-resistant cancer therapy in the future.

KW - Breast cancer

KW - Cell apoptosis

KW - Furanodiene

KW - Intrinsic/extrinsic apoptosis

KW - Multidrug resistance

KW - NF-κB

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JO - Frontiers in Pharmacology

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ER -

Furanodiene induces extrinsic and intrinsic apoptosis in doxorubicin-resistant MCF-7 breast cancer cells via NF-κB-independent mechanism

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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