Abstract
Herpesviruses are double-stranded DNA, enveloped viruses that infect host cells through fusion with either the host cell plasma membrane or endocytic vesicle membranes. Efficient infection of host cells by herpesviruses is remarkably more complex than infection by other viruses, as it requires the concerted effort of multiple glycoproteins and involves multiple host receptors. The structures of the major viral glycoproteins and a number of host receptors involved in the entry of the prototypical herpesviruses, the herpes simplex viruses (HSVs) and Epstein-Barr virus (EBV), are now known. These structural studies have accelerated our understanding of HSV and EBV binding and fusion by revealing the conformational changes that occur on virus-receptor binding, depicting potential sites of functional protein and lipid interactions, and identifying the probable viral fusogen.
Original language | English (US) |
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Pages (from-to) | 369-381 |
Number of pages | 13 |
Journal | Nature Reviews Microbiology |
Volume | 9 |
Issue number | 5 |
DOIs | |
State | Published - May 2011 |
Funding
Research in the Jardetzky and Longnecker laboratories was supported by US Public Health Service grants (AI076183 and CA117794 to T.S.J., and AI076183, CA117794 and AI067048 to R.L.). The authors thank current and former members of their laboratories for their contributions to the work described, as well as their many colleagues throughout the world who have contributed to understanding the entry of EBV, HSV and other herpesviruses.
ASJC Scopus subject areas
- Microbiology
- General Immunology and Microbiology
- Infectious Diseases