Gadofluorine-enhanced magnetic resonance imaging of carotid atherosclerosis in Yucatan miniswine

Ioannis Koktzoglou; Kathleen R. Harris; Richard Tang; Bonnie J. Kane; Bernd Misselwitz; Hanns Joachim Weinmann; Biao Lu; Ashwin Nagaraj; Sanford I. Roth; Timothy J. Carroll; David D. McPherson; Debiao Li

doi:10.1097/01.rli.0000188362.12555.62

Gadofluorine-enhanced magnetic resonance imaging of carotid atherosclerosis in Yucatan miniswine

Ioannis Koktzoglou^*, Kathleen R. Harris, Richard Tang, Bonnie J. Kane, Bernd Misselwitz, Hanns Joachim Weinmann, Biao Lu, Ashwin Nagaraj, Sanford I. Roth, Timothy J. Carroll, David D. McPherson, Debiao Li

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

OBJECTIVE: The aim of this study was to determine whether gadofluorine, a paramagnetic magnetic resonance imaging (MRI) contrast agent, selectively enhances carotid atherosclerotic plaques in Yucatan miniswine. METHODS: Atherosclerotic plaques were induced in the left carotid arteries (LCA) of Yucatan miniswine (n = 3) by balloon denudation and high cholesterol diet. T1-weighted MRI was performed before and 24 hours after gadofluorine injection (at a dose of 100 μmol/kg) to assess the enhancement of the balloon-injured LCA wall relative to healthy, uninjured right carotid artery (RCA) wall. Histopathology was performed to verify the presence and composition of the atherosclerotic plaques imaged with MRI. RESULTS: Gadofluorine was found to enhance LCA atherosclerotic lesions relative to RCA wall by 21% (P < 0.025) 24 hours after contrast injection. Enhancement of healthy LCA wall relative to healthy RCA wall was not observed. CONCLUSION: Gadofluorine selectively enhances carotid atherosclerotic plaques in Yucatan miniswine. Gadofluorine appears to be a promising MR contrast agent for detection of atherosclerotic plaques in vivo.

Original language	English (US)
Pages (from-to)	299-304
Number of pages	6
Journal	Investigative radiology
Volume	41
Issue number	3
DOIs	https://doi.org/10.1097/01.rli.0000188362.12555.62
State	Published - Mar 2006

Keywords

Atherosclerosis
Contrast agents
Gadofluorine
Magnetic resonance imaging
Vessel wall imaging

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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title = "Gadofluorine-enhanced magnetic resonance imaging of carotid atherosclerosis in Yucatan miniswine",

abstract = "OBJECTIVE: The aim of this study was to determine whether gadofluorine, a paramagnetic magnetic resonance imaging (MRI) contrast agent, selectively enhances carotid atherosclerotic plaques in Yucatan miniswine. METHODS: Atherosclerotic plaques were induced in the left carotid arteries (LCA) of Yucatan miniswine (n = 3) by balloon denudation and high cholesterol diet. T1-weighted MRI was performed before and 24 hours after gadofluorine injection (at a dose of 100 μmol/kg) to assess the enhancement of the balloon-injured LCA wall relative to healthy, uninjured right carotid artery (RCA) wall. Histopathology was performed to verify the presence and composition of the atherosclerotic plaques imaged with MRI. RESULTS: Gadofluorine was found to enhance LCA atherosclerotic lesions relative to RCA wall by 21% (P < 0.025) 24 hours after contrast injection. Enhancement of healthy LCA wall relative to healthy RCA wall was not observed. CONCLUSION: Gadofluorine selectively enhances carotid atherosclerotic plaques in Yucatan miniswine. Gadofluorine appears to be a promising MR contrast agent for detection of atherosclerotic plaques in vivo.",

keywords = "Atherosclerosis, Contrast agents, Gadofluorine, Magnetic resonance imaging, Vessel wall imaging",

author = "Ioannis Koktzoglou and Harris, {Kathleen R.} and Richard Tang and Kane, {Bonnie J.} and Bernd Misselwitz and Weinmann, {Hanns Joachim} and Biao Lu and Ashwin Nagaraj and Roth, {Sanford I.} and Carroll, {Timothy J.} and McPherson, {David D.} and Debiao Li",

year = "2006",

month = mar,

doi = "10.1097/01.rli.0000188362.12555.62",

language = "English (US)",

volume = "41",

pages = "299--304",

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T1 - Gadofluorine-enhanced magnetic resonance imaging of carotid atherosclerosis in Yucatan miniswine

AU - Koktzoglou, Ioannis

AU - Harris, Kathleen R.

AU - Tang, Richard

AU - Kane, Bonnie J.

AU - Misselwitz, Bernd

AU - Weinmann, Hanns Joachim

AU - Lu, Biao

AU - Nagaraj, Ashwin

AU - Roth, Sanford I.

AU - Carroll, Timothy J.

AU - McPherson, David D.

AU - Li, Debiao

PY - 2006/3

Y1 - 2006/3

N2 - OBJECTIVE: The aim of this study was to determine whether gadofluorine, a paramagnetic magnetic resonance imaging (MRI) contrast agent, selectively enhances carotid atherosclerotic plaques in Yucatan miniswine. METHODS: Atherosclerotic plaques were induced in the left carotid arteries (LCA) of Yucatan miniswine (n = 3) by balloon denudation and high cholesterol diet. T1-weighted MRI was performed before and 24 hours after gadofluorine injection (at a dose of 100 μmol/kg) to assess the enhancement of the balloon-injured LCA wall relative to healthy, uninjured right carotid artery (RCA) wall. Histopathology was performed to verify the presence and composition of the atherosclerotic plaques imaged with MRI. RESULTS: Gadofluorine was found to enhance LCA atherosclerotic lesions relative to RCA wall by 21% (P < 0.025) 24 hours after contrast injection. Enhancement of healthy LCA wall relative to healthy RCA wall was not observed. CONCLUSION: Gadofluorine selectively enhances carotid atherosclerotic plaques in Yucatan miniswine. Gadofluorine appears to be a promising MR contrast agent for detection of atherosclerotic plaques in vivo.

AB - OBJECTIVE: The aim of this study was to determine whether gadofluorine, a paramagnetic magnetic resonance imaging (MRI) contrast agent, selectively enhances carotid atherosclerotic plaques in Yucatan miniswine. METHODS: Atherosclerotic plaques were induced in the left carotid arteries (LCA) of Yucatan miniswine (n = 3) by balloon denudation and high cholesterol diet. T1-weighted MRI was performed before and 24 hours after gadofluorine injection (at a dose of 100 μmol/kg) to assess the enhancement of the balloon-injured LCA wall relative to healthy, uninjured right carotid artery (RCA) wall. Histopathology was performed to verify the presence and composition of the atherosclerotic plaques imaged with MRI. RESULTS: Gadofluorine was found to enhance LCA atherosclerotic lesions relative to RCA wall by 21% (P < 0.025) 24 hours after contrast injection. Enhancement of healthy LCA wall relative to healthy RCA wall was not observed. CONCLUSION: Gadofluorine selectively enhances carotid atherosclerotic plaques in Yucatan miniswine. Gadofluorine appears to be a promising MR contrast agent for detection of atherosclerotic plaques in vivo.

KW - Atherosclerosis

KW - Contrast agents

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KW - Magnetic resonance imaging

KW - Vessel wall imaging

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Gadofluorine-enhanced magnetic resonance imaging of carotid atherosclerosis in Yucatan miniswine

Abstract

Keywords

ASJC Scopus subject areas

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