Gadofluorine-enhanced magnetic resonance imaging of carotid atherosclerosis in Yucatan miniswine

Ioannis Koktzoglou*, Kathleen R. Harris, Richard Tang, Bonnie J. Kane, Bernd Misselwitz, Hanns Joachim Weinmann, Biao Lu, Ashwin Nagaraj, Sanford I. Roth, Timothy J. Carroll, David D. McPherson, Debiao Li

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

OBJECTIVE: The aim of this study was to determine whether gadofluorine, a paramagnetic magnetic resonance imaging (MRI) contrast agent, selectively enhances carotid atherosclerotic plaques in Yucatan miniswine. METHODS: Atherosclerotic plaques were induced in the left carotid arteries (LCA) of Yucatan miniswine (n = 3) by balloon denudation and high cholesterol diet. T1-weighted MRI was performed before and 24 hours after gadofluorine injection (at a dose of 100 μmol/kg) to assess the enhancement of the balloon-injured LCA wall relative to healthy, uninjured right carotid artery (RCA) wall. Histopathology was performed to verify the presence and composition of the atherosclerotic plaques imaged with MRI. RESULTS: Gadofluorine was found to enhance LCA atherosclerotic lesions relative to RCA wall by 21% (P < 0.025) 24 hours after contrast injection. Enhancement of healthy LCA wall relative to healthy RCA wall was not observed. CONCLUSION: Gadofluorine selectively enhances carotid atherosclerotic plaques in Yucatan miniswine. Gadofluorine appears to be a promising MR contrast agent for detection of atherosclerotic plaques in vivo.

Original languageEnglish (US)
Pages (from-to)299-304
Number of pages6
JournalInvestigative radiology
Volume41
Issue number3
DOIs
StatePublished - Mar 1 2006

Keywords

  • Atherosclerosis
  • Contrast agents
  • Gadofluorine
  • Magnetic resonance imaging
  • Vessel wall imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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