Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion

Kun Jiang, Carl R. Rankin, Porfirio Nava, Ronen Sumagin, Ryuta Kamekura, Sean R. Stowell, Mingli Feng, Charles A. Parkos, Asma Nusrat*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Background: Desmoglein-2 mediates intestinal epithelial intercellular adhesion. Results: Galectin-3 was identified to associate with the ectodomain of desmoglein-2 and inhibit the degradation of desmoglein- 2 and enhance intercellular adhesion. Conclusion: Galectin-3 lattices stabilize desmoglein-2 at the cell surface to regulate intercellular adhesion in intestinal epithelial cells. Significance: This study identifies a novel role of galectin-3 in controlling desmosome structure and function.

Original languageEnglish (US)
Pages (from-to)10510-10517
Number of pages8
JournalJournal of Biological Chemistry
Volume289
Issue number15
DOIs
StatePublished - Apr 11 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion'. Together they form a unique fingerprint.

Cite this