Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion

Kun Jiang; Carl R. Rankin; Porfirio Nava; Ronen Sumagin; Ryuta Kamekura; Sean R. Stowell; Mingli Feng; Charles A. Parkos; Asma Nusrat

doi:10.1074/jbc.M113.538538

Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion

Kun Jiang, Carl R. Rankin, Porfirio Nava, Ronen Sumagin, Ryuta Kamekura, Sean R. Stowell, Mingli Feng, Charles A. Parkos, Asma Nusrat^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Background: Desmoglein-2 mediates intestinal epithelial intercellular adhesion. Results: Galectin-3 was identified to associate with the ectodomain of desmoglein-2 and inhibit the degradation of desmoglein- 2 and enhance intercellular adhesion. Conclusion: Galectin-3 lattices stabilize desmoglein-2 at the cell surface to regulate intercellular adhesion in intestinal epithelial cells. Significance: This study identifies a novel role of galectin-3 in controlling desmosome structure and function.

Original language	English (US)
Pages (from-to)	10510-10517
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	289
Issue number	15
DOIs	https://doi.org/10.1074/jbc.M113.538538
State	Published - Apr 11 2014

Funding

ASJC Scopus subject areas

Molecular Biology
Biochemistry
Cell Biology

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title = "Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion",

abstract = "Background: Desmoglein-2 mediates intestinal epithelial intercellular adhesion. Results: Galectin-3 was identified to associate with the ectodomain of desmoglein-2 and inhibit the degradation of desmoglein- 2 and enhance intercellular adhesion. Conclusion: Galectin-3 lattices stabilize desmoglein-2 at the cell surface to regulate intercellular adhesion in intestinal epithelial cells. Significance: This study identifies a novel role of galectin-3 in controlling desmosome structure and function.",

author = "Kun Jiang and Rankin, {Carl R.} and Porfirio Nava and Ronen Sumagin and Ryuta Kamekura and Stowell, {Sean R.} and Mingli Feng and Parkos, {Charles A.} and Asma Nusrat",

year = "2014",

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doi = "10.1074/jbc.M113.538538",

language = "English (US)",

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T1 - Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion

AU - Jiang, Kun

AU - Rankin, Carl R.

AU - Nava, Porfirio

AU - Sumagin, Ronen

AU - Kamekura, Ryuta

AU - Stowell, Sean R.

AU - Feng, Mingli

AU - Parkos, Charles A.

AU - Nusrat, Asma

PY - 2014/4/11

Y1 - 2014/4/11

N2 - Background: Desmoglein-2 mediates intestinal epithelial intercellular adhesion. Results: Galectin-3 was identified to associate with the ectodomain of desmoglein-2 and inhibit the degradation of desmoglein- 2 and enhance intercellular adhesion. Conclusion: Galectin-3 lattices stabilize desmoglein-2 at the cell surface to regulate intercellular adhesion in intestinal epithelial cells. Significance: This study identifies a novel role of galectin-3 in controlling desmosome structure and function.

AB - Background: Desmoglein-2 mediates intestinal epithelial intercellular adhesion. Results: Galectin-3 was identified to associate with the ectodomain of desmoglein-2 and inhibit the degradation of desmoglein- 2 and enhance intercellular adhesion. Conclusion: Galectin-3 lattices stabilize desmoglein-2 at the cell surface to regulate intercellular adhesion in intestinal epithelial cells. Significance: This study identifies a novel role of galectin-3 in controlling desmosome structure and function.

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Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion

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