TY - JOUR
T1 - Gallamine administered by combined bolus and infusion
AU - Shanks, C. A.
AU - Funk, D. I.
AU - Avram, M. J.
AU - Henthorn, T. K.
PY - 1982
Y1 - 1982
N2 - A technique combining an intravenous bolus and intravenous infusion regimen of gallamine based on its pharmacokinetics was developed to produce continuous relaxation during surgery. The combination of a bolus dose of gallamine, 2.5 mg/kg, and infusion, 0.8 mg/kg/hr, was tested in 11 patients. In 10 patients, surgery continued long enough to allow demonstration of an apparent plateau in the serum gallamine concentrations. At the cessation of the infusion, the mean gallamine concentration of 11.8 μg/ml was associated with an average paralysis intensity of 92%. Pharmacokinetic analysis of the gallamine serum concentration-time data was fitted to a three-compartment model. In this study of 50- to 76-year-old patients, the most striking difference from other studies was that the elimination half-life averaged 247 minutes in this study whereas 128 to 141 minutes has been reported previously.
AB - A technique combining an intravenous bolus and intravenous infusion regimen of gallamine based on its pharmacokinetics was developed to produce continuous relaxation during surgery. The combination of a bolus dose of gallamine, 2.5 mg/kg, and infusion, 0.8 mg/kg/hr, was tested in 11 patients. In 10 patients, surgery continued long enough to allow demonstration of an apparent plateau in the serum gallamine concentrations. At the cessation of the infusion, the mean gallamine concentration of 11.8 μg/ml was associated with an average paralysis intensity of 92%. Pharmacokinetic analysis of the gallamine serum concentration-time data was fitted to a three-compartment model. In this study of 50- to 76-year-old patients, the most striking difference from other studies was that the elimination half-life averaged 247 minutes in this study whereas 128 to 141 minutes has been reported previously.
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U2 - 10.1213/00000539-198210000-00009
DO - 10.1213/00000539-198210000-00009
M3 - Article
C2 - 6289700
AN - SCOPUS:0019926087
VL - 61
SP - 847
EP - 852
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
SN - 0003-2999
IS - 10
ER -