gamma-Aminobutyric acid (GABA) uptake by Xenopus oocytes injected with rat brain mRNA.

V. Sarthy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A major pathway for inactivation of biogenic amine and amino acid neurotransmitters is by uptake into neurons or glia cells through Na+-dependent, high-affinity uptake systems. Here, we show that Xenopus oocytes, microinjected with poly(A)+ RNA from developing rat brain, express a Na+-dependent GABA uptake system, which is similar in its properties to the high-affinity GABA uptake system, present in rat brain. These results suggest that the oocyte expression system may be useful in the isolation of mRNAs and subsequent cloning of the genes encoding the polypeptides involved in GABA transport in the nervous system.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalBrain research
Volume387
Issue number1
StatePublished - Jul 1986

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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