Ganglioside GM3 promotes carcinoma cell proliferation via urokinase plasminogen activator-induced extracellular signal-regulated kinase-independent p70S6 kinase signaling

Keyphrases

• Cell Proliferation 100%
• Urokinase-type Plasminogen Activator 100%
• Ganglioside GM3 100%
• Carcinoma Cells 100%
• Extracellular Signal-regulated Kinase 100%
• Kinase-independent 100%
• Kinase Signaling 100%
• P70S6K 100%
• Gangliosides 75%
• Overexpression 50%
• Threonine 50%
• Neoplastic Cells 50%
• Tumor Cells 25%
• Phosphorylation 25%
• Protein Kinase C Activation 25%
• Phosphoinositide 3-kinase (PI3K) 25%
• Receptor Signaling 25%
• Epithelial Cells 25%
• Soluble Urokinase Plasminogen Activator Receptor (suPAR) 25%
• Melanoma 25%
• Therapeutic Modalities 25%
• Fibronectin 25%
• Epidermal Growth Factor 25%
• Epidermal Growth Factor Receptor 25%
• Kinase Activation 25%
• Local Concentration 25%
• Tumor Cell Membrane 25%
• Ligand-dependent 25%
• Concomitant Treatment 25%
• Extracellular Signal-regulated Kinase Signaling 25%
• Cutaneous Tumors 25%
• Extracellular Signal-regulated Kinase Activation 25%
• Ligand-independent Activation 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Phosphotransferase 100%
• Ganglioside GM3 100%
• Mitogen Activated Protein Kinase 100%
• Carcinoma 100%
• Urokinase 100%
• Ganglioside 60%
• Receptor 40%
• Epidermal Growth Factor Receptor 40%
• Threonine 40%
• Serine 40%
• Phosphatidylinositol 3 Kinase 20%
• Melanoma 20%
• Fibronectin 20%
• Skin Tumor 20%
• Protein Kinase C 20%
• Neoplasm 20%
• Epidermal Growth Factor 20%
• Urokinase Receptor 20%

Biochemistry, Genetics and Molecular Biology

• GM3 100%
• Cell Proliferation 100%
• Extracellular Signal-Regulated Kinases 100%
• P70S6 Kinase 100%
• Urokinase 100%
• Ganglioside 100%
• Epidermal Growth Factor Receptor 28%
• Serine 28%
• Threonine 28%
• Enhancer Region 14%
• Phosphoinositide 3-Kinase 14%
• Protein Kinase C 14%
• Cell Membrane 14%
• Urokinase Receptor 14%
• Epidermal Growth Factor 14%
• Fibronectin 14%