Gap junctions and motor behavior

Ole Kiehn*, Matthew C. Tresch

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations

Abstract

The production of any motor behavior requires coordinated activity in motor neurons and premotor networks. In vertebrates, this coordination is often assumed to take place through chemical synapses. Here we review recent data suggesting that electrical gap-junction coupling plays an important role in coordinating and generating motor outputs in embryonic and early postnatal life. Considering the recent demonstration of a prevalent expression of gap-junction proteins and gap-junction structures in the adult mammalian spinal cord, we suggest that neuronal gap-junction coupling might also contribute to the production of motor behavior in adult mammals.

Original languageEnglish (US)
Pages (from-to)108-115
Number of pages8
JournalTrends in Neurosciences
Volume25
Issue number2
DOIs
StatePublished - Feb 1 2002

ASJC Scopus subject areas

  • Neuroscience(all)

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