Gastric inflammation during systemic anaphylaxis: Neutrophil recruitment in stomach wall of mice does not require mast cell participation

Glenn T. Furuta, Zheng Sheng Wang, Barry K. Wershil*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

We determined whether neutrophil infiltration into the stomach wall occurred during systemic anaphylaxis in mice and assessed the participation of mast cells in the response. Normal mice sensitized and challenged with antigen exhibited significant neutrophil infiltration in the gastric mucosa and submucosa compared with saline-challenged mice. The development of clinical signs of anaphylaxis and extent of gastric neutrophil infiltration was similar in mast cell-deficient Kit(W)/Kit(W-v) or Mgf(Sl)/Mgf(Sl-d) mice and the respective normal congenic mice. Pretreatment with sodium cromoglycate prevented the clinical signs of anaphylaxis and significantly diminished the infiltration of neutrophils in +/+ or Kit(W)/Kit(W-v) mice. Systemic anaphylaxis is associated with neutrophil infiltration into the stomach wall in mice, and mast cells are not required for the development of either the clinical manifestations or gastric neutrophil infiltration observed in the response.

Original languageEnglish (US)
Pages (from-to)2021-2027
Number of pages7
JournalDigestive diseases and sciences
Volume43
Issue number9
DOIs
StatePublished - 1998

Keywords

  • Anaphylaxis
  • Cromolyn
  • Degranulation
  • Mast cell
  • Mucosa
  • Neutrophil
  • Stomach
  • Submucosa

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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