Gastrointestinal and renal excretion of potassium in African-Americans and White Americans

Robert M. Rosa*, Ernest De Jesus, Kevin Sperling, Annie Suh, Aleksandra Gmurczyk, Kevin A. Myrie, Karol Rosner, Edgar Lerma, William Yu, Richard Breuer, James B. Young

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Objective: Several studies have confirmed the remarkable observation that cumulative urinary potassium (K) excretion is less in African-Americans than White Americans even when identical amounts of potassium are provided in the diet. This study was designed to examine whether this decrease in urinary potassium could be compensatory to an increase in gastrointestinal excretion of potassium in African-Americans. Methods: Twenty-three young, healthy, normotensive participants of both sexes and races were placed on a fixed diet of 100 mEq per day of K and 180 mEq per day of sodium (Na) for 9 days. All urine and stool were collected daily and analyzed for electrolytes. Blood was obtained for determination of electrolytes, blood urea nitrogen (BUN), creatinine, glucose, insulin, renin, and aldosterone at the beginning and at the end of the study period. Results: Cumulative urinary excretion of K was significantly less in African-Americans (609 ± 31 mEq) compared with White Americans (713 ± 22 mEq, P = 0.015). There was no significant racial difference, however, in the cumulative gastrointestinal excretion of K (105 ± 11 versus 95 ± 9 mEq, P = 0.28) in African-Americans versus White Americans, respectively. Conclusion: The racial difference in urinary K handling manifested by decreased excretion of K in African-Americans cannot be attributed to an increase in net gastrointestinal excretion of this cation.

Original languageEnglish (US)
Pages (from-to)2373-2377
Number of pages5
JournalJournal of hypertension
Issue number12
StatePublished - Dec 2012


  • African-Americans
  • gastrointestinal excretion
  • potassium
  • renal excretion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology
  • Internal Medicine


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